Drug metabolizing enzyme systems and their relationship to toxic mechanisms
The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs.
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| Format: | Article in Journal/Newspaper |
| Language: | English |
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National Cancer Inst., Bethesda, MD (USA)
1983
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| Online Access: | https://digital.library.unt.edu/ark:/67531/metadc1056446/ |
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ftunivnotexas:info:ark/67531/metadc1056446 2023-05-15T15:52:36+02:00 Drug metabolizing enzyme systems and their relationship to toxic mechanisms Boyd, M. R. Ravindranath, V. Burka, L. T. Dutcher, J. S. Franklin, R. B. Statham, C. N. Haschek, W. M. Hakkinen, P. J. Morse, C. C. Witschi, H. P. 1983-01-01 10 pages Text https://digital.library.unt.edu/ark:/67531/metadc1056446/ English eng National Cancer Inst., Bethesda, MD (USA) Oak Ridge National Laboratory other: DE86002242 rep-no: CONF-8309285-2 grantno: AC05-84OR21400 osti: 5010978 https://digital.library.unt.edu/ark:/67531/metadc1056446/ ark: ark:/67531/metadc1056446 Symposium on new approaches in toxicity testing and their application to human risk assessment, St. Louis, MO, USA, 14 Sep 1983 Body Lungs Mammals Chromatography Glands Cell Proliferation Organic Compounds Mixed-Function Oxidases Semicarbazones Liver Mice Vertebrates 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987) Oxidoreductases Glutathione Conjugates Metabolic Activation Separation Processes Animals 59 Basic Biological Sciences Liquid Column Chromatography Respiratory System Organic Oxygen Compounds Enzyme Activity Toxicity Autoradiography Furans Gel Permeation Chromatography 63 Radiation Thermal And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat Heterocyclic Compounds Organs Digestive System Carbonic Acid Derivatives Oxygenases Pathological Changes Enzymes 550501 -- Metabolism-- Tracer Techniques Organic Nitrogen Compounds Kidneys Metabolites Rodents Article 1983 ftunivnotexas 2021-04-24T22:08:01Z The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs. Article in Journal/Newspaper Carbonic acid University of North Texas: UNT Digital Library |
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Open Polar |
| collection |
University of North Texas: UNT Digital Library |
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ftunivnotexas |
| language |
English |
| topic |
Body Lungs Mammals Chromatography Glands Cell Proliferation Organic Compounds Mixed-Function Oxidases Semicarbazones Liver Mice Vertebrates 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987) Oxidoreductases Glutathione Conjugates Metabolic Activation Separation Processes Animals 59 Basic Biological Sciences Liquid Column Chromatography Respiratory System Organic Oxygen Compounds Enzyme Activity Toxicity Autoradiography Furans Gel Permeation Chromatography 63 Radiation Thermal And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat Heterocyclic Compounds Organs Digestive System Carbonic Acid Derivatives Oxygenases Pathological Changes Enzymes 550501 -- Metabolism-- Tracer Techniques Organic Nitrogen Compounds Kidneys Metabolites Rodents |
| spellingShingle |
Body Lungs Mammals Chromatography Glands Cell Proliferation Organic Compounds Mixed-Function Oxidases Semicarbazones Liver Mice Vertebrates 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987) Oxidoreductases Glutathione Conjugates Metabolic Activation Separation Processes Animals 59 Basic Biological Sciences Liquid Column Chromatography Respiratory System Organic Oxygen Compounds Enzyme Activity Toxicity Autoradiography Furans Gel Permeation Chromatography 63 Radiation Thermal And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat Heterocyclic Compounds Organs Digestive System Carbonic Acid Derivatives Oxygenases Pathological Changes Enzymes 550501 -- Metabolism-- Tracer Techniques Organic Nitrogen Compounds Kidneys Metabolites Rodents Boyd, M. R. Ravindranath, V. Burka, L. T. Dutcher, J. S. Franklin, R. B. Statham, C. N. Haschek, W. M. Hakkinen, P. J. Morse, C. C. Witschi, H. P. Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| topic_facet |
Body Lungs Mammals Chromatography Glands Cell Proliferation Organic Compounds Mixed-Function Oxidases Semicarbazones Liver Mice Vertebrates 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987) Oxidoreductases Glutathione Conjugates Metabolic Activation Separation Processes Animals 59 Basic Biological Sciences Liquid Column Chromatography Respiratory System Organic Oxygen Compounds Enzyme Activity Toxicity Autoradiography Furans Gel Permeation Chromatography 63 Radiation Thermal And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat Heterocyclic Compounds Organs Digestive System Carbonic Acid Derivatives Oxygenases Pathological Changes Enzymes 550501 -- Metabolism-- Tracer Techniques Organic Nitrogen Compounds Kidneys Metabolites Rodents |
| description |
The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs. |
| format |
Article in Journal/Newspaper |
| author |
Boyd, M. R. Ravindranath, V. Burka, L. T. Dutcher, J. S. Franklin, R. B. Statham, C. N. Haschek, W. M. Hakkinen, P. J. Morse, C. C. Witschi, H. P. |
| author_facet |
Boyd, M. R. Ravindranath, V. Burka, L. T. Dutcher, J. S. Franklin, R. B. Statham, C. N. Haschek, W. M. Hakkinen, P. J. Morse, C. C. Witschi, H. P. |
| author_sort |
Boyd, M. R. |
| title |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_short |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_full |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_fullStr |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_full_unstemmed |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_sort |
drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| publisher |
National Cancer Inst., Bethesda, MD (USA) |
| publishDate |
1983 |
| url |
https://digital.library.unt.edu/ark:/67531/metadc1056446/ |
| genre |
Carbonic acid |
| genre_facet |
Carbonic acid |
| op_source |
Symposium on new approaches in toxicity testing and their application to human risk assessment, St. Louis, MO, USA, 14 Sep 1983 |
| op_relation |
other: DE86002242 rep-no: CONF-8309285-2 grantno: AC05-84OR21400 osti: 5010978 https://digital.library.unt.edu/ark:/67531/metadc1056446/ ark: ark:/67531/metadc1056446 |
| _version_ |
1766387735904387072 |