Drug metabolizing enzyme systems and their relationship to toxic mechanisms

The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs.

Bibliographic Details
Main Authors:	Boyd, M. R., Ravindranath, V., Burka, L. T., Dutcher, J. S., Franklin, R. B., Statham, C. N., Haschek, W. M., Hakkinen, P. J., Morse, C. C., Witschi, H. P.
Format:	Article in Journal/Newspaper
Language:	English
Published:	National Cancer Inst., Bethesda, MD (USA) 1983
Subjects:	Body Lungs Mammals Chromatography Glands Cell Proliferation Organic Compounds Mixed-Function Oxidases Semicarbazones Liver Mice Vertebrates 560305* > Chemicals Metabolism & Toxicology > Vertebrates > (-1987) Oxidoreductases Glutathione Conjugates Metabolic Activation Separation Processes Animals 59 Basic Biological Sciences Liquid Column Chromatography Respiratory System Organic Oxygen Compounds Enzyme Activity Toxicity Autoradiography Furans Gel Permeation Chromatography 63 Radiation Thermal And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat Heterocyclic Compounds Organs Digestive System Carbonic Acid Derivatives Oxygenases Pathological Changes Enzymes 550501 > Metabolism > Tracer Techniques Organic Nitrogen Compounds Kidneys Metabolites Rodents Carbonic acid
Online Access:	https://digital.library.unt.edu/ark:/67531/metadc1056446/

Description
Summary:	The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs.