Organic Radical Contrast Agents for Magnetic Resonance Imaging

We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) that has molecular r1 ≈ 5 mM−1s−1. The ORCA is based on spirocyclohexyl nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine dendrimers scaffold. T...

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Main Authors: Rajca, Andrzej, Wang, Ying, Boska, Michael, Paletta, Joseph T., Olankitwanit, Arnon, Swanson, Michael A., Mitchell, Deborah G., Eaton, Sandra S., Eaton, Gareth R., Rajca, Suchada
Format: Text
Language:unknown
Published: DigitalCommons@University of Nebraska - Lincoln 2012
Subjects:
Orca
Online Access:https://digitalcommons.unl.edu/chemistryrajca/9
https://digitalcommons.unl.edu/context/chemistryrajca/article/1008/viewcontent/Rajca_JACS_2012_Organic_Radical.pdf
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spelling ftunivnebraskali:oai:digitalcommons.unl.edu:chemistryrajca-1008 2023-11-12T04:24:05+01:00 Organic Radical Contrast Agents for Magnetic Resonance Imaging Rajca, Andrzej Wang, Ying Boska, Michael Paletta, Joseph T. Olankitwanit, Arnon Swanson, Michael A. Mitchell, Deborah G. Eaton, Sandra S. Eaton, Gareth R. Rajca, Suchada 2012-01-01T08:00:00Z application/pdf https://digitalcommons.unl.edu/chemistryrajca/9 https://digitalcommons.unl.edu/context/chemistryrajca/article/1008/viewcontent/Rajca_JACS_2012_Organic_Radical.pdf unknown DigitalCommons@University of Nebraska - Lincoln https://digitalcommons.unl.edu/chemistryrajca/9 https://digitalcommons.unl.edu/context/chemistryrajca/article/1008/viewcontent/Rajca_JACS_2012_Organic_Radical.pdf Andrzej Rajca Publications text 2012 ftunivnebraskali 2023-10-30T11:28:16Z We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) that has molecular r1 ≈ 5 mM−1s−1. The ORCA is based on spirocyclohexyl nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine dendrimers scaffold. The metal-free ORCA has a long shelf-life and provides selectively enhanced MRI in mice for over 1 h. Text Orca University of Nebraska-Lincoln: DigitalCommons@UNL
institution Open Polar
collection University of Nebraska-Lincoln: DigitalCommons@UNL
op_collection_id ftunivnebraskali
language unknown
description We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) that has molecular r1 ≈ 5 mM−1s−1. The ORCA is based on spirocyclohexyl nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine dendrimers scaffold. The metal-free ORCA has a long shelf-life and provides selectively enhanced MRI in mice for over 1 h.
format Text
author Rajca, Andrzej
Wang, Ying
Boska, Michael
Paletta, Joseph T.
Olankitwanit, Arnon
Swanson, Michael A.
Mitchell, Deborah G.
Eaton, Sandra S.
Eaton, Gareth R.
Rajca, Suchada
spellingShingle Rajca, Andrzej
Wang, Ying
Boska, Michael
Paletta, Joseph T.
Olankitwanit, Arnon
Swanson, Michael A.
Mitchell, Deborah G.
Eaton, Sandra S.
Eaton, Gareth R.
Rajca, Suchada
Organic Radical Contrast Agents for Magnetic Resonance Imaging
author_facet Rajca, Andrzej
Wang, Ying
Boska, Michael
Paletta, Joseph T.
Olankitwanit, Arnon
Swanson, Michael A.
Mitchell, Deborah G.
Eaton, Sandra S.
Eaton, Gareth R.
Rajca, Suchada
author_sort Rajca, Andrzej
title Organic Radical Contrast Agents for Magnetic Resonance Imaging
title_short Organic Radical Contrast Agents for Magnetic Resonance Imaging
title_full Organic Radical Contrast Agents for Magnetic Resonance Imaging
title_fullStr Organic Radical Contrast Agents for Magnetic Resonance Imaging
title_full_unstemmed Organic Radical Contrast Agents for Magnetic Resonance Imaging
title_sort organic radical contrast agents for magnetic resonance imaging
publisher DigitalCommons@University of Nebraska - Lincoln
publishDate 2012
url https://digitalcommons.unl.edu/chemistryrajca/9
https://digitalcommons.unl.edu/context/chemistryrajca/article/1008/viewcontent/Rajca_JACS_2012_Organic_Radical.pdf
genre Orca
genre_facet Orca
op_source Andrzej Rajca Publications
op_relation https://digitalcommons.unl.edu/chemistryrajca/9
https://digitalcommons.unl.edu/context/chemistryrajca/article/1008/viewcontent/Rajca_JACS_2012_Organic_Radical.pdf
_version_ 1782338660147920896

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