Organic Radical Contrast Agents for Magnetic Resonance Imaging
We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) that has molecular r1 ≈ 5 mM−1s−1. The ORCA is based on spirocyclohexyl nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine dendrimers scaffold. T...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Text |
Language: | unknown |
Published: |
DigitalCommons@University of Nebraska - Lincoln
2012
|
Subjects: | |
Online Access: | https://digitalcommons.unl.edu/chemistryrajca/9 https://digitalcommons.unl.edu/context/chemistryrajca/article/1008/viewcontent/Rajca_JACS_2012_Organic_Radical.pdf |
Summary: | We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) that has molecular r1 ≈ 5 mM−1s−1. The ORCA is based on spirocyclohexyl nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine dendrimers scaffold. The metal-free ORCA has a long shelf-life and provides selectively enhanced MRI in mice for over 1 h. |
---|