Identification of a Sorbicillinoid-Producing Aspergillus Strain with Antimicrobial Activity Against Staphylococcus aureus: a New Polyextremophilic Marine Fungus from Barents Sea

The exploration of poorly studied areas of Earth can highly increase the possibility to discover novel bioactive compounds. In this study, the cultivable fraction of fungi and bacteria from Barents Sea sediments has been studied to mine new bioactive molecules with antibacterial activity against a p...

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Bibliographic Details
Published in:Marine Biotechnology
Main Authors: Corral, Paulina, PALMA ESPOSITO, FORTUNATO, Tedesco, Pietro, Falco, Angela, Tortorella, Emiliana, Tartaglione, Luciana, Festa, Carmen, D’Auria, Maria Valeria, Gnavi, Giorgio, Varese, Giovanna Cristina, de Pascale, Donatella
Other Authors: PALMA ESPOSITO, Fortunato
Format: Article in Journal/Newspaper
Language:English
Published: 2018
Subjects:
MDR
Online Access:http://hdl.handle.net/11588/722387
https://doi.org/10.1007/s10126-018-9821-9
http://link.springer.com/journal/volumesAndIssues/10126
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Summary:The exploration of poorly studied areas of Earth can highly increase the possibility to discover novel bioactive compounds. In this study, the cultivable fraction of fungi and bacteria from Barents Sea sediments has been studied to mine new bioactive molecules with antibacterial activity against a panel of human pathogens. We isolated diverse strains of psychrophilic and halophilic bacteria and fungi from a collection of nine samples from sea sediment. Following a full bioassay-guided approach, we isolated a new promising polyextremophilic marine fungus strain 8Na, identified as Aspergillusprotuberus MUT 3638, possessing the potential to produce antimicrobial agents. This fungus, isolated from cold seawater, was able to grow in a wide range of salinity, pH and temperatures. The growth conditions were optimised and scaled to fermentation, and its produced extract was subjected to chemical analysis. The active component was identified as bisvertinolone, a member of sorbicillonoid family that was found to display significant activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 30 μg/mL. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.