Seoul Orthohantavirus in Wild Black Rats, Senegal, 2012–2013

• Published in: Emerging Infectious Diseases
• Main Authors: Diagne, Moussa, Dieng, Idrissa, Granjon, Laurent, Lucaccioni, Héloïse, Sow, Abdourahmane, Ndiaye, Oumar, Faye, Martin, Bâ, Khalilou, Bâ, Yamar, Diallo, Mamoudou, Faye, Oumar, Duplantier, Jean-Marc, Diallo, Mawlouth, Handschumacher, Pascal, Faye, Ousmane, Sall, Amadou
• Other Authors: Institut Pasteur de Dakar, Réseau International des Instituts Pasteur (RIIP), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD France-Sud )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université Paris Nanterre (UPN), Institut de recherche pour le développement Dakar, Sénégal (IRD Hann Maristes), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by grant nos. ANR-11-CE-PL-0010 and ANR-11-JSV7-0006 (A.A.S., O.F., M.M.D., A.G., Y.B., M.D.) from the Agence Nationale de la Recherche., ANR-11-CEPL-0010,CHANCIRA,CHANgements environnementaux, CIrculation de biens et de personnes : de l'invasion de réservoirs à l'apparition d'anthropozoonoses. le cas du RAt noir dans l'espace sénégalo-malien(2011), ANR-11-JSV7-0006,ENEMI,Conséquences évolutives des ennemis naturels dans des invasions biologiques majeures : le rôle des parasites dans le succès de l'invasion de deux rongeurs commensaux(2011)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2020
• Subjects: Hantavirus; Rattus rattus; Senegal; Seoul orthohantavirus; black rats; rodents; viruses; zoonoses; [SDV]Life Sciences [q-bio]
• Online Access: https://www.hal.inserm.fr/inserm-03192861; https://www.hal.inserm.fr/inserm-03192861/document; https://www.hal.inserm.fr/inserm-03192861/file/20-1306-combined.pdf; https://doi.org/10.3201/eid2610.201306

International audience Hantaviruses (family Hantaviridae, genus Ortho-hantavirus) are RNA viruses transmitted by aero-solized excreta from infected rodents and shrews. In humans, they cause hemorrhagic fever with renal syndrome (more often observed in Asia and Europe) and cardiopulmonary syndrome (more common in the Americas) (1). Only 1 case has been confirmed in Africa, in the Central African Republic in 1987 (2). However, studies from 2006 through 2013 have discovered new hantaviruses in autochthonous African rodents, moles, and bats (3,4). In addition, serologic evidence in humans and rodents in Africa suggest local circulation (5). For example, a study in rural areas of Senegal found 11.5% of rodents and 16.6% of humans had antibodies against hantaviruses (3). More recently, serologic evidence of hantaviruses was reported in domestic and peridomestic rodents from some regions in Senegal (6). Southeastern Senegal has become a major trade area because of urbanization and substantial improvement of its road and rail networks in the late 1990s (7). Within a few years, these changes led to the rapid spread of a major invasive rodent species, the black rat (Rattus rattus [family Murinae]), which is a reservoir for Seoul orthohantavirus (SEOV) (4,5,7). To assess the prevalence of hantaviruses in rodents, we screened for hantaviruses in R. rattus rats and commensal or peridomestic co-existing rodents in 2012–2013, approximately 15 years after the 1998 opening of a tarred road in eastern Senegal.