Articles Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

• Published in: The Lancet Diabetes & Endocrinology
• Main Authors: Wu, Y, Marklund, Matti, Imamura, Fumiaki, Tintle, Nathan, Korat, Ardisson, de Goede, Janette, Zhou, Xia, Yang, Wei-Sin, de Oliveira Otto, Marcia C, Kröger, Janine, Qureshi, Waqas, Virtanen, Jyrki, Bassett, Julie, Frazier-Wood, Alexis, Lankinen, Maria, Murphy, Rachel, Rajaobelina, Kalina, Gobbo, Del, Forouhi, Nita, Luben, Robert, Khaw, Kay-Tee, Wareham, Nick, Kalsbeek, Anya, Veenstra, Jenna, Luo, Juhua, Hu, Frank, Lin, Hung-Ju, Siscovick, David, Boeing, Heiner, Chen, Tzu-An, Steffen, Brian, Steffen, Lyn, Hodge, Allison, Eriksdottir, Gudny, Smith, Albert, Gudnason, Vilmunder, Harris, Tamara, Brouwer, Ingeborg, Berr, Claudine, Helmer, Catherine, Samieri, Cecilia, Laakso, Markku, Tsai, Michael, Giles, Graham, Nurmi, Tarja, Wagenknecht, Lynne, Schulze, Matthias, Lemaitre, Rozenn, Chien, Kuo-Liong, Soedamah-Muthu, Sabita
• Other Authors: The George Institute for Global Health Sydney (GIGH), The University of Sydney, Department of Public Health and Caring Sciences Uppsala, Sweden (Clinical Nutrition and Metabolism), Uppsala University-Clinical Nutrition and Metabolism Uppsala, Sweden, Medical Research Council Epidemiology Unit Cambridge, UK, University of Cambridge UK (CAM), Department of Mathematics and Statistics Sioux Center, IA, USA, Dordt College, Departments of Epidemiology and Nutrition Boston, MA, USA, Harvard School of Public Health, Division of Human Nutrition Wageningen, Netherlands, Wageningen University and Research Wageningen (WUR), School of Public Health Minneapolis, MN, États-Unis, University of Minnesota Twin Cities (UMN), University of Minnesota System-University of Minnesota System, Institute of Epidemiology and Preventive Medicine Taipei, Taiwan, National Taiwan University Taiwan (NTU), Human Genetics and Environmental Sciences Houston, TX, USA (Division of Epidemiology), The University of Texas Health Science Center at Houston (UTHealth)-School of Public Health Houston, TX, USA, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Wake Forest University, Institute of Public Health and Clinical Nutrition Kuopio, Finland, University of Eastern Finland, Cancer Council Victoria Melbourne, VIC, Australia, US Department of Agriculture/Agricultural Research Service Houston, TX, USA, Children's Nutrition Research Center Houston, TX, USA, University of British Columbia (UBC), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Stanford Medicine, Stanford University, Department of Public Health and Primary Care Cambridge, UK (Institute of Public Health), Department of Biology Sioux Center, IA, USA, Department of Epidemiology and Biostatistics Bloomington, IN, USA, Indiana University Bloomington, Indiana University System-Indiana University System, School of Medicine Taipei, Taiwan, National Yang-Ming University Taipei, Taiwan, The New York Academy of Medicine New York, NY, USA, Department of Laboratory Medicine and Pathology Minneapolis, MN, USA, University of Minnesota Medical School, Icelandic Heart Institute Kópavogur, Iceland, National Institute on Aging Bethesda, MD, USA, Athena Institute for Research on Innovation and Communication in Health and Life Sciences Amsterdam, Pays-Bas, Vrije Universiteit Amsterdam Amsterdam (VU), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institute of Clinical Medicine Kuopio, Finland, Cardiovascular Health Research Unit Seattle, WA, USA (Department of Medicine), University of Washington Seattle
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2017
• Subjects: [SDV]Life Sciences [q-bio]; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Iceland
• Online Access: https://www.hal.inserm.fr/inserm-02466524; https://www.hal.inserm.fr/inserm-02466524/document; https://www.hal.inserm.fr/inserm-02466524/file/Wu%20%20Lancet%20diabetes%20Endoc%202017%20omega%206%26diabetes.pdf; https://doi.org/10.1016/S2213-8587(17)30307-8

Comment in Linoleic acid and risk of type 2 diabetes. [Lancet Diabetes Endocrinol. 2017] Diabetes: Omega-6 PUFAs and T2DM. [Nat Rev Endocrinol. 2017] Linoleic acid and diabetes prevention. [Lancet Diabetes Endocrinol. 2018] Linoleic acid and diabetes prevention - Authors' reply. [Lancet Diabetes Endocrinol. 2018] International audience BACKGROUND:The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes.METHODS:We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled between 1970 and 2010. Participants included in the analyses were aged 18 years or older and had data available for linoleic acid and arachidonic acid biomarkers at baseline. We excluded participants with type 2 diabetes at baseline. The main outcome was the association between omega-6 PUFA biomarkers and incident type 2 diabetes. We assessed the relative risk of type 2 diabetes prospectively for each cohort and lipid compartment separately using a prespecified analytic plan for exposures, covariates, effect modifiers, and analysis, and the findings were then pooled using inverse-variance weighted meta-analysis.FINDINGS:Participants were 39 740 adults, aged (range of cohort means) 49-76 years with a BMI (range of cohort means) of 23·3-28·4 kg/m2, who did not have type 2 diabetes at baseline. During a follow-up of 366 073 person-years, we identified 4347 cases of incident type 2 diabetes. In multivariable-adjusted pooled analyses, higher proportions of linoleic acid biomarkers as percentages of ...