Inter-population variations in concentrations, determinants of and correlations between 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE): A cross-sectional study of 3161 men and women from Inuit and European populations

The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlor...

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Bibliographic Details
Published in:Environmental Health
Main Authors: JONSSON BO AG, RYLANDER L, LINDH C, RIGNELL HYDBOM A, GIWERCMAN A, TOFT G, PEDERSEN HS, LUDWICKI JK, GORALCZYK K, ZVYEZDAY V, SPANO M, BIZZARO D, BONEFELD JORGENSEN EC, MANICARDI, Gian Carlo, BONDE JP AND HAGMAR L.
Other Authors: JONSSON BO, Ag, Rylander, L, Lindh, C, RIGNELL HYDBOM, A, Giwercman, A, Toft, G, Pedersen, H, Ludwicki, Jk, Goralczyk, K, Zvyezday, V, Spano, M, Bizzaro, D, BONEFELD JORGENSEN, Ec, Manicardi, Gian Carlo, BONDE JP AND HAGMAR, L.
Format: Article in Journal/Newspaper
Language:English
Published: London : BioMed Central, [2002- 2005
Subjects:
POP
human fertility
POP-biomarkers
inuit
inuits
Online Access:http://hdl.handle.net/11380/455194
https://doi.org/10.1186/1476-069X-4-27
Description
Summary:The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers. CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the POP-biomarkers varied considerably between the populations, underlining that exposure sources differ and that the choice of representative biomarkers of overall POP exposure has to be based on an analysis of the specific exposure situation for each population. Age and gender were consistent determinants of serum POPs; seafood was of importance only in the Inuit and Swedish populations.

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