Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality.
Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene–environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHR...
Published in: | Reproductive Toxicology |
---|---|
Main Authors: | , , , , , , , , , , , , |
Other Authors: | , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2014
|
Subjects: | |
Online Access: | http://hdl.handle.net/11380/1038319 https://doi.org/10.1016/j.reprotox.2014.07.073 |
id |
ftunivmodena:oai:iris.unimore.it:11380/1038319 |
---|---|
record_format |
openpolar |
spelling |
ftunivmodena:oai:iris.unimore.it:11380/1038319 2024-04-21T08:04:06+00:00 Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. 1.0.2. Brokken LJS Lundberg PJ Spanò M Pedersen HS Struciński P Góralczyk K Zviezdai V Jönsson BAG Bonde JP Toft G Lundberg Giwercman Y Giwercman A. MANICARDI, Gian Carlo Brokken LJS, 1. 0. 2. Lundberg, Pj Spanò, M Manicardi, Gian Carlo Pedersen, H Struciński, P Góralczyk, K Zviezdai, V Jönsson, Bag Bonde, Jp Toft, G Lundberg Giwercman, Y Giwercman, A. 2014 STAMPA http://hdl.handle.net/11380/1038319 https://doi.org/10.1016/j.reprotox.2014.07.073 eng eng info:eu-repo/semantics/altIdentifier/pmid/25084496 info:eu-repo/semantics/altIdentifier/wos/WOS:000345257900008 volume:49 firstpage:65 lastpage:73 journal:REPRODUCTIVE TOXICOLOGY http://hdl.handle.net/11380/1038319 doi:10.1016/j.reprotox.2014.07.073 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84907323511 info:eu-repo/semantics/closedAccess Cross-sectional studie Gene–environment interaction Single nucleotide polymorphism Aryl hydrocarbon receptor info:eu-repo/semantics/article 2014 ftunivmodena https://doi.org/10.1016/j.reprotox.2014.07.073 2024-03-28T01:27:34Z Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene–environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene ( p,p -DDE) and 2,2 ,4,4 ,5,5 -hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p -DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling Article in Journal/Newspaper greenlandic Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) Reproductive Toxicology 49 65 73 |
institution |
Open Polar |
collection |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
op_collection_id |
ftunivmodena |
language |
English |
topic |
Cross-sectional studie Gene–environment interaction Single nucleotide polymorphism Aryl hydrocarbon receptor |
spellingShingle |
Cross-sectional studie Gene–environment interaction Single nucleotide polymorphism Aryl hydrocarbon receptor 1.0.2. Brokken LJS Lundberg PJ Spanò M Pedersen HS Struciński P Góralczyk K Zviezdai V Jönsson BAG Bonde JP Toft G Lundberg Giwercman Y Giwercman A. MANICARDI, Gian Carlo Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. |
topic_facet |
Cross-sectional studie Gene–environment interaction Single nucleotide polymorphism Aryl hydrocarbon receptor |
description |
Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene–environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene ( p,p -DDE) and 2,2 ,4,4 ,5,5 -hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p -DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling |
author2 |
Brokken LJS, 1. 0. 2. Lundberg, Pj Spanò, M Manicardi, Gian Carlo Pedersen, H Struciński, P Góralczyk, K Zviezdai, V Jönsson, Bag Bonde, Jp Toft, G Lundberg Giwercman, Y Giwercman, A. |
format |
Article in Journal/Newspaper |
author |
1.0.2. Brokken LJS Lundberg PJ Spanò M Pedersen HS Struciński P Góralczyk K Zviezdai V Jönsson BAG Bonde JP Toft G Lundberg Giwercman Y Giwercman A. MANICARDI, Gian Carlo |
author_facet |
1.0.2. Brokken LJS Lundberg PJ Spanò M Pedersen HS Struciński P Góralczyk K Zviezdai V Jönsson BAG Bonde JP Toft G Lundberg Giwercman Y Giwercman A. MANICARDI, Gian Carlo |
author_sort |
1.0.2. Brokken LJS |
title |
Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. |
title_short |
Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. |
title_full |
Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. |
title_fullStr |
Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. |
title_full_unstemmed |
Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. |
title_sort |
interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. |
publishDate |
2014 |
url |
http://hdl.handle.net/11380/1038319 https://doi.org/10.1016/j.reprotox.2014.07.073 |
genre |
greenlandic |
genre_facet |
greenlandic |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/25084496 info:eu-repo/semantics/altIdentifier/wos/WOS:000345257900008 volume:49 firstpage:65 lastpage:73 journal:REPRODUCTIVE TOXICOLOGY http://hdl.handle.net/11380/1038319 doi:10.1016/j.reprotox.2014.07.073 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84907323511 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.reprotox.2014.07.073 |
container_title |
Reproductive Toxicology |
container_volume |
49 |
container_start_page |
65 |
op_container_end_page |
73 |
_version_ |
1796943712596525056 |