Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality.

Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene–environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHR...

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Bibliographic Details
Published in:Reproductive Toxicology
Main Authors: 1.0.2. Brokken LJS, Lundberg PJ, Spanò M, Pedersen HS, Struciński P, Góralczyk K, Zviezdai V, Jönsson BAG, Bonde JP, Toft G, Lundberg Giwercman Y, Giwercman A., MANICARDI, Gian Carlo
Other Authors: Brokken LJS, 1. 0. 2., Lundberg, Pj, Spanò, M, Manicardi, Gian Carlo, Pedersen, H, Struciński, P, Góralczyk, K, Zviezdai, V, Jönsson, Bag, Bonde, Jp, Toft, G, Lundberg Giwercman, Y, Giwercman, A.
Format: Article in Journal/Newspaper
Language:English
Published: 2014
Subjects:
Cross-sectional studie
Gene–environment interaction
Single nucleotide polymorphism
Aryl hydrocarbon receptor
greenlandic
Online Access:http://hdl.handle.net/11380/1038319
https://doi.org/10.1016/j.reprotox.2014.07.073
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Summary:Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene–environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene ( p,p -DDE) and 2,2 ,4,4 ,5,5 -hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p -DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling

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