Development and characterization of nanostructured lipid carriers for cannabidiol delivery

Supplementary data to this article can be found online at https://doi.org/10.1016/j.foodchem.2023.138295. This study evaluated the physicochemical characteristics of nanostructured lipid carriers (NLCs) as a potential vehicle for cannabidiol (CBD), a lipophilic molecule with great potential to promo...

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Bibliographic Details
Published in:Food Chemistry
Main Authors: Vardanega, Renata, Lüdtke, Fernanda Luisa, Loureiro, Luís Carlos Sá, Gonçalves, Raquel Filipa Silva, Pinheiro, A. C., Vicente, A. A.
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier Science BV 2024
Subjects:
Drug Carriers
Health Promotion
Soybean Oil
Emulsifying Agents
Particle Size
Polysorbates
Nanoparticles
Cannabidiol
Nanostructures
Cannabinoids
Emulsifiers
Lipid nanoparticles
Lipid-based systems
Nanoparticles characterization
Physical stability
Norway
Iceland
Online Access:https://hdl.handle.net/1822/89366
https://doi.org/10.1016/j.foodchem.2023.138295
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Summary:Supplementary data to this article can be found online at https://doi.org/10.1016/j.foodchem.2023.138295. This study evaluated the physicochemical characteristics of nanostructured lipid carriers (NLCs) as a potential vehicle for cannabidiol (CBD), a lipophilic molecule with great potential to promote health benefits. NLCs were produced using hemp seed oil and fully-hydrogenated soybean oil at different proportions. The emulsifiers evaluated were soybean lecithin (SL), Tween 80 (T80) and a mixture of SL:T80 (50:50). CBD was tested in the form of CBD-rich extract or isolate CBD, to verify if it affects the NLCs characteristics. Based on particle size and polydispersity, SL was considered the most suitable emulsifier to produce the NLCs. All lipid proportions evaluated had no remarkable effect on the physicochemical characteristics of NLCs, resulting in CBD-loaded NLCs with particle size below 250 nm, high CBD entrapment efficiency and CBD retention rate of 100% for 30 days, demonstrating that NLCs are a suitable vehicle for both CBD-rich extract or isolate CBD. This study received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie SkłodowskaCurie grant agreement No 101062938 and was supported by Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit, and by LABBELS – Associate Laboratory in Biotechnology, Bioengineering and Microelectromechanical Systems, LA/P/0029/2020. Fernanda L. Lüdtke thanks Iceland Liechtenstein Norway Grants (PT-INNOVATION-0105) for the fellowship.

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