A complex scenario of tuberculosis transmission is revealed through genetic and epidemiological surveys in Porto

Tuberculosis (TB) incidence is decreasing worldwide and eradication is becoming plausible. In low-incidence countries, intervention on migrant populations is considered one of the most important strategies for elimination. However, such measures are inappropriate in European areas where TB is largel...

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Bibliographic Details
Published in:BMC Infectious Diseases
Main Authors: Rito, Teresa S, Matos, Carlos, Carvalho, Carlos, Machado, Henrique Pedro Pereira Silva Amaral, Rodrigues, Gabriela, Oliveira, Olena, Ferreira, Eduarda, Gonçalves, Jorge, Maio, Lurdes, Morais, Clara, Ramos, Helena, Guimarães, João Tiago, Santos, Catarina L., Duarte, Raquel, Correia-Neves, M
Format: Article in Journal/Newspaper
Language:English
Published: Springer Nature 2018
Subjects:
Female
Genotype
Humans
Minisatellite Repeats
Molecular Epidemiology
Mycobacterium tuberculosis
Portugal
Socioeconomic Factors
Tuberculosis
Genotyping techniques
Epidemiology of tuberculosis
Phylogenetic analysis
Public health
Ciências Médicas::Medicina Básica
Science & Technology
Norway
Iceland
Online Access:http://hdl.handle.net/1822/57932
https://doi.org/10.1186/s12879-018-2968-1
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Summary:Tuberculosis (TB) incidence is decreasing worldwide and eradication is becoming plausible. In low-incidence countries, intervention on migrant populations is considered one of the most important strategies for elimination. However, such measures are inappropriate in European areas where TB is largely endemic, such as Porto in Portugal. We aim to understand transmission chains in Porto through a genetic characterization of Mycobacterium tuberculosis strains and through a detailed epidemiological evaluation of cases. This work was developed under the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER), and supported by contributions from Iceland, Liechtenstein and Norway through the European Economic Area Grants under the Public Health Initiative programme, (PT06, Project 000138DT1). TR is supported by the Portuguese Foundation for Science and Technology (FCT) through a post-doctoral grant (SFRH/BPD/108126/2015) ...

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