Enzymatic continuous-flow preparation of nature-inspired phenolic esters as antiradical and antimicrobial noagents

A collection of nature-inspired lipophilic phenolic esters have been prepared by an enzymatic synthesis under flow conditions, using the immobilized lipase B from Candida antarctica (Novozyme 435 (R)) as a catalyst in cyclopentyl methyl ether (CPME), a non-conventional and green solvent. Their antim...

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Bibliographic Details
Published in:Food Chemistry
Main Authors: Annunziata, Francesca, Contente, Martina L, Anzi, Valentina, Donzella, Silvia, Conti, Paola, Molinari, Francesco, Martino, Piera Anna, Meroni, Gabriele, Sora, Valerio Massimo, Tamborini, Lucia, Pinto, Andrea
Other Authors: F. Annunziata, M.L. Contente, V. Anzi, S. Donzella, P. Conti, F. Molinari, P.A. Martino, G. Meroni, V.M. Sora, L. Tamborini, A. Pinto
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier 2022
Subjects:
Antimicrobial agent
Flow chemistry
Food preservative
Lipase
Phenolic ester
Radical scavenger
Antioxidant
Enzymes
Immobilized
Fungal Protein
Phenol
Anti-Infective Agent
Esters
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/10 - Chimica degli Alimenti
Antarc*
Antarctica
Online Access:http://hdl.handle.net/2434/937212
https://doi.org/10.1016/j.foodchem.2022.133195
Description
Summary:A collection of nature-inspired lipophilic phenolic esters have been prepared by an enzymatic synthesis under flow conditions, using the immobilized lipase B from Candida antarctica (Novozyme 435 (R)) as a catalyst in cyclopentyl methyl ether (CPME), a non-conventional and green solvent. Their antimicrobial activity against four selected bacterial strains together with their efficiency as radical scavengers were evaluated. The obtained compounds were characterized by enhanced lipophilicity in comparison with the parent non-esterified compounds, which increased the possibility of their use as additives in the food industry.

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