A practical chemoenzymatic approach to the synthesis of 3-hydroxy metabolites of tibolone

Stereoselective preparation of 3-hydroxy metabolites of tibolone is easily accomplished by diastereoselective Candida antarctica lipase b-catalyzed transformations of 3alpha- and 3-beta-alcohols or acetates mixtures in organic solvents, in suitable amounts for biological studies.

Bibliographic Details
Published in:Tetrahedron: Asymmetry
Main Authors: P. Ferraboschi, D. Colombo, S. Reza Elahi
Other Authors: S. Reza-Elahi
Format: Article in Journal/Newspaper
Language:English
Published: Pergamon Elsevier Science 2002
Subjects:
Settore BIO/10 - Biochimica
Antarc*
Antarctica
Online Access:http://hdl.handle.net/2434/26017
https://doi.org/10.1016/S0957-4166(02)00712-7
Description
Summary:Stereoselective preparation of 3-hydroxy metabolites of tibolone is easily accomplished by diastereoselective Candida antarctica lipase b-catalyzed transformations of 3alpha- and 3-beta-alcohols or acetates mixtures in organic solvents, in suitable amounts for biological studies.

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