Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzym...
| Published in: | Bioorganic & Medicinal Chemistry Letters |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Elsevier Science Ltd
1999
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| Subjects: | |
| Online Access: | http://hdl.handle.net/2434/144329 https://doi.org/10.1016/S0960-894X(99)00228-0 |
| _version_ | 1821698360895078400 |
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| author | P. Ciuffreda S. Casati E. Santaniello |
| author2 | P. Ciuffreda S. Casati E. Santaniello |
| author_facet | P. Ciuffreda S. Casati E. Santaniello |
| author_sort | P. Ciuffreda |
| collection | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| container_issue | 11 |
| container_start_page | 1577 |
| container_title | Bioorganic & Medicinal Chemistry Letters |
| container_volume | 9 |
| description | The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine has been achieved |
| format | Article in Journal/Newspaper |
| genre | Antarc* Antarctica |
| genre_facet | Antarc* Antarctica |
| id | ftunivmilanoair:oai:air.unimi.it:2434/144329 |
| institution | Open Polar |
| language | English |
| op_collection_id | ftunivmilanoair |
| op_container_end_page | 1582 |
| op_doi | https://doi.org/10.1016/S0960-894X(99)00228-0 |
| op_relation | info:eu-repo/semantics/altIdentifier/pmid/10386939 info:eu-repo/semantics/altIdentifier/wos/WOS:000080757600020 volume:9 issue:11 firstpage:1577 lastpage:1582 journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS http://hdl.handle.net/2434/144329 doi:10.1016/S0960-894X(99)00228-0 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033532651 |
| publishDate | 1999 |
| publisher | Elsevier Science Ltd |
| record_format | openpolar |
| spelling | ftunivmilanoair:oai:air.unimi.it:2434/144329 2025-01-16T19:15:46+00:00 Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine P. Ciuffreda S. Casati E. Santaniello P. Ciuffreda S. Casati E. Santaniello 1999-06-07 http://hdl.handle.net/2434/144329 https://doi.org/10.1016/S0960-894X(99)00228-0 eng eng Elsevier Science Ltd info:eu-repo/semantics/altIdentifier/pmid/10386939 info:eu-repo/semantics/altIdentifier/wos/WOS:000080757600020 volume:9 issue:11 firstpage:1577 lastpage:1582 journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS http://hdl.handle.net/2434/144329 doi:10.1016/S0960-894X(99)00228-0 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033532651 Settore BIO/10 - Biochimica info:eu-repo/semantics/article 1999 ftunivmilanoair https://doi.org/10.1016/S0960-894X(99)00228-0 2024-01-02T23:26:32Z The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine has been achieved Article in Journal/Newspaper Antarc* Antarctica The University of Milan: Archivio Istituzionale della Ricerca (AIR) Bioorganic & Medicinal Chemistry Letters 9 11 1577 1582 |
| spellingShingle | Settore BIO/10 - Biochimica P. Ciuffreda S. Casati E. Santaniello Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine |
| title | Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine |
| title_full | Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine |
| title_fullStr | Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine |
| title_full_unstemmed | Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine |
| title_short | Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine |
| title_sort | lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine |
| topic | Settore BIO/10 - Biochimica |
| topic_facet | Settore BIO/10 - Biochimica |
| url | http://hdl.handle.net/2434/144329 https://doi.org/10.1016/S0960-894X(99)00228-0 |