Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine

The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzym...

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Published in:Bioorganic & Medicinal Chemistry Letters
Main Authors: P. Ciuffreda, S. Casati, E. Santaniello
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier Science Ltd 1999
Subjects:
Settore BIO/10 - Biochimica
Antarc*
Antarctica
Online Access:http://hdl.handle.net/2434/144329
https://doi.org/10.1016/S0960-894X(99)00228-0
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spelling ftunivmilanoair:oai:air.unimi.it:2434/144329 2024-01-28T09:59:55+01:00 Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine P. Ciuffreda S. Casati E. Santaniello P. Ciuffreda S. Casati E. Santaniello 1999-06-07 http://hdl.handle.net/2434/144329 https://doi.org/10.1016/S0960-894X(99)00228-0 eng eng Elsevier Science Ltd info:eu-repo/semantics/altIdentifier/pmid/10386939 info:eu-repo/semantics/altIdentifier/wos/WOS:000080757600020 volume:9 issue:11 firstpage:1577 lastpage:1582 journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS http://hdl.handle.net/2434/144329 doi:10.1016/S0960-894X(99)00228-0 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033532651 Settore BIO/10 - Biochimica info:eu-repo/semantics/article 1999 ftunivmilanoair https://doi.org/10.1016/S0960-894X(99)00228-0 2024-01-02T23:26:32Z The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine has been achieved Article in Journal/Newspaper Antarc* Antarctica The University of Milan: Archivio Istituzionale della Ricerca (AIR) Bioorganic & Medicinal Chemistry Letters 9 11 1577 1582
institution Open Polar
collection The University of Milan: Archivio Istituzionale della Ricerca (AIR)
op_collection_id ftunivmilanoair
language English
topic Settore BIO/10 - Biochimica
spellingShingle Settore BIO/10 - Biochimica
P. Ciuffreda
S. Casati
E. Santaniello
Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
topic_facet Settore BIO/10 - Biochimica
description The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine has been achieved
author2 P. Ciuffreda
S. Casati
E. Santaniello
format Article in Journal/Newspaper
author P. Ciuffreda
S. Casati
E. Santaniello
author_facet P. Ciuffreda
S. Casati
E. Santaniello
author_sort P. Ciuffreda
title Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
title_short Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
title_full Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
title_fullStr Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
title_full_unstemmed Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
title_sort lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
publisher Elsevier Science Ltd
publishDate 1999
url http://hdl.handle.net/2434/144329
https://doi.org/10.1016/S0960-894X(99)00228-0
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation info:eu-repo/semantics/altIdentifier/pmid/10386939
info:eu-repo/semantics/altIdentifier/wos/WOS:000080757600020
volume:9
issue:11
firstpage:1577
lastpage:1582
journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
http://hdl.handle.net/2434/144329
doi:10.1016/S0960-894X(99)00228-0
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033532651
op_doi https://doi.org/10.1016/S0960-894X(99)00228-0
container_title Bioorganic & Medicinal Chemistry Letters
container_volume 9
container_issue 11
container_start_page 1577
op_container_end_page 1582
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