Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzym...
| Published in: | Bioorganic & Medicinal Chemistry Letters |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Elsevier Science Ltd
1999
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| Subjects: | |
| Online Access: | http://hdl.handle.net/2434/144329 https://doi.org/10.1016/S0960-894X(99)00228-0 |
| Summary: | The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine has been achieved |
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