| Summary: | Facultad de Ciencias Médicas y Biológicas. Maestría en Ciencias de la Salud Ochratoxins are mycotoxins produced by fungal species of the Aspergillus and Penicillium genera, which are known due to their nephrotoxic and immunosuppressive activity; the most toxic and frequent is ochratoxin A (OTA). The potential risk of mycotoxin consumption by companion animals has gained importance due to the increase in extruded pet food. Although dogs belong to the Order Carnivora, extruded pet food often contain relatively high amounts of cereals and cereal by-products from the extrusion process. In other animal species, OTA causes chronic kidney disease; however, doses considered toxic or lethal to dogs have not been reported in the clinical literature. The objective of this study was to determine the degree of OTA contamination in commercial extruded food for domestic canines and its correlation with their plasma concentration to determine the degree of exposure to OTA in the state of Michoacán. Two types of samples were used: samples of different brands of commercial extruded food in sealed package and in bulk, available in commercial establishments in the city of Morelia, Michoacán, and blood samples from domestic canines that have been fed with these types of food. The sampling stage lasted 6 months, during which different commercial brands of extruded food were selected. Representative samples were obtained and were grinded to reduce their particle size. Several clinics, hospitals and veterinary clinical laboratories were visited in order to obtain samples from clinically healthy canine patients and patients with diagnosed of chronic renal disease, who consume commercial extruded food. Ochratoxigenic fungi and yeasts were quantified in extruded food. Las ocratoxinas son micotoxinas producidas por especies fúngicas de los géneros Aspergillus y Penicillium, las cuales presentan actividad nefrotóxica e inmunosupresora, siendo la más tóxica y frecuente la ocratoxina A (OTA). El riesgo potencial del consumo de micotoxinas ...
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