Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study
Persons with type 2 diabetes are at increased risk of cognitive dysfunction. Less is known about which cognitive abilities are affected and how undiagnosed diabetes and impaired fasting glucose relate to cognitive performance. The authors explored this question using data from 1,917 nondemented men...
Published in: | American Journal of Epidemiology |
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Online Access: | https://doi.org/10.1093/aje/kwn228 https://hdl.handle.net/20.500.14038/47629 https://escholarship.umassmed.edu/qhs_pp/756 |
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ftunivmassmm:oai:repository.escholarship.umassmed.edu:20.500.14038/47629 2023-05-15T16:51:22+02:00 Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study Saczynski, Jane S. Jonsdottir, Maria K. Garcia, Melissa E. Jonsson, Palmi V. Peila, Rita Eiriksdottir, Gudny Olafsdottir, Elin Harris, Tamara B. Gudnason, Vilmundur Launer, Lenore J. Meyers Primary Care Institute Department of Quantitative Health Sciences Department of Medicine, Division of Geriatric Medicine 2022-08-11T08:10:42.000 https://doi.org/10.1093/aje/kwn228 https://hdl.handle.net/20.500.14038/47629 https://escholarship.umassmed.edu/qhs_pp/756 en_US eng Link to Article in PubMed http://dx.doi.org/10.1093/aje/kwn228 Am J Epidemiol. 2008 Nov 15;168(10):1132-9. Epub 2008 Oct 3. Link to article on publisher's site 0002-9262 (Linking) doi:10.1093/aje/kwn228 18836152 http://hdl.handle.net/20.500.14038/47629 https://escholarship.umassmed.edu/qhs_pp/756 1396379 qhs_pp/756 American journal of epidemiology 168 10 1132-9 Aged Blood Glucose Cognition Disorders Cohort Studies Diabetes Mellitus Type 2 Environment Fasting Female Genetic Predisposition to Disease Glycemic Index Hemoglobin A Glycosylated Humans Iceland Logistic Models Male Psychological Tests Questionnaires Biostatistics Epidemiology Health Services Research Journal Article 2022 ftunivmassmm https://doi.org/10.1093/aje/kwn228 https://doi.org/20.500.14038/47629 2023-01-05T18:39:13Z Persons with type 2 diabetes are at increased risk of cognitive dysfunction. Less is known about which cognitive abilities are affected and how undiagnosed diabetes and impaired fasting glucose relate to cognitive performance. The authors explored this question using data from 1,917 nondemented men and women (average age = 76 years) in the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (2002-2006). Glycemic status groups included diagnosed diabetes (self-reported diabetes or diabetic medication use; n = 163 (8.5%)), undiagnosed diabetes (fasting blood glucose >or=7.0 mmol/L without diagnosed diabetes; n = 55 (2.9%)), and impaired fasting glucose (fasting blood glucose 5.6-6.9 mmol/L; n = 744 (38.8%)). Composites of memory, processing speed (PS), and executive function were constructed from a neuropsychological battery. Linear regression was used to investigate cross-sectional differences in cognitive performance between glycemic groups, adjusted for demographic and health factors. Persons with diagnosed diabetes had slower PS than normoglycemics (beta = -0.12; P < 0.05); diabetes duration of >or=15 years was associated with significantly poorer PS and executive function. Undiagnosed diabetics had slower PS (beta = -0.22; P < 0.01) and poorer memory performance (beta = -0.22; P < 0.05). Persons with type 2 diabetes have poorer cognitive performance than normoglycemics, particularly in PS. Those with undiagnosed diabetes have the lowest cognitive performance. Article in Journal/Newspaper Iceland University of Massachusetts, Medical School: eScholarship@UMMS American Journal of Epidemiology 168 10 1132 1139 |
institution |
Open Polar |
collection |
University of Massachusetts, Medical School: eScholarship@UMMS |
op_collection_id |
ftunivmassmm |
language |
English |
topic |
Aged Blood Glucose Cognition Disorders Cohort Studies Diabetes Mellitus Type 2 Environment Fasting Female Genetic Predisposition to Disease Glycemic Index Hemoglobin A Glycosylated Humans Iceland Logistic Models Male Psychological Tests Questionnaires Biostatistics Epidemiology Health Services Research |
spellingShingle |
Aged Blood Glucose Cognition Disorders Cohort Studies Diabetes Mellitus Type 2 Environment Fasting Female Genetic Predisposition to Disease Glycemic Index Hemoglobin A Glycosylated Humans Iceland Logistic Models Male Psychological Tests Questionnaires Biostatistics Epidemiology Health Services Research Saczynski, Jane S. Jonsdottir, Maria K. Garcia, Melissa E. Jonsson, Palmi V. Peila, Rita Eiriksdottir, Gudny Olafsdottir, Elin Harris, Tamara B. Gudnason, Vilmundur Launer, Lenore J. Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
topic_facet |
Aged Blood Glucose Cognition Disorders Cohort Studies Diabetes Mellitus Type 2 Environment Fasting Female Genetic Predisposition to Disease Glycemic Index Hemoglobin A Glycosylated Humans Iceland Logistic Models Male Psychological Tests Questionnaires Biostatistics Epidemiology Health Services Research |
description |
Persons with type 2 diabetes are at increased risk of cognitive dysfunction. Less is known about which cognitive abilities are affected and how undiagnosed diabetes and impaired fasting glucose relate to cognitive performance. The authors explored this question using data from 1,917 nondemented men and women (average age = 76 years) in the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (2002-2006). Glycemic status groups included diagnosed diabetes (self-reported diabetes or diabetic medication use; n = 163 (8.5%)), undiagnosed diabetes (fasting blood glucose >or=7.0 mmol/L without diagnosed diabetes; n = 55 (2.9%)), and impaired fasting glucose (fasting blood glucose 5.6-6.9 mmol/L; n = 744 (38.8%)). Composites of memory, processing speed (PS), and executive function were constructed from a neuropsychological battery. Linear regression was used to investigate cross-sectional differences in cognitive performance between glycemic groups, adjusted for demographic and health factors. Persons with diagnosed diabetes had slower PS than normoglycemics (beta = -0.12; P < 0.05); diabetes duration of >or=15 years was associated with significantly poorer PS and executive function. Undiagnosed diabetics had slower PS (beta = -0.22; P < 0.01) and poorer memory performance (beta = -0.22; P < 0.05). Persons with type 2 diabetes have poorer cognitive performance than normoglycemics, particularly in PS. Those with undiagnosed diabetes have the lowest cognitive performance. |
author2 |
Meyers Primary Care Institute Department of Quantitative Health Sciences Department of Medicine, Division of Geriatric Medicine |
format |
Article in Journal/Newspaper |
author |
Saczynski, Jane S. Jonsdottir, Maria K. Garcia, Melissa E. Jonsson, Palmi V. Peila, Rita Eiriksdottir, Gudny Olafsdottir, Elin Harris, Tamara B. Gudnason, Vilmundur Launer, Lenore J. |
author_facet |
Saczynski, Jane S. Jonsdottir, Maria K. Garcia, Melissa E. Jonsson, Palmi V. Peila, Rita Eiriksdottir, Gudny Olafsdottir, Elin Harris, Tamara B. Gudnason, Vilmundur Launer, Lenore J. |
author_sort |
Saczynski, Jane S. |
title |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_short |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_full |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_fullStr |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_full_unstemmed |
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study |
title_sort |
cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--reykjavik study |
publishDate |
2022 |
url |
https://doi.org/10.1093/aje/kwn228 https://hdl.handle.net/20.500.14038/47629 https://escholarship.umassmed.edu/qhs_pp/756 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
American journal of epidemiology 168 10 1132-9 |
op_relation |
Link to Article in PubMed http://dx.doi.org/10.1093/aje/kwn228 Am J Epidemiol. 2008 Nov 15;168(10):1132-9. Epub 2008 Oct 3. Link to article on publisher's site 0002-9262 (Linking) doi:10.1093/aje/kwn228 18836152 http://hdl.handle.net/20.500.14038/47629 https://escholarship.umassmed.edu/qhs_pp/756 1396379 qhs_pp/756 |
op_doi |
https://doi.org/10.1093/aje/kwn228 https://doi.org/20.500.14038/47629 |
container_title |
American Journal of Epidemiology |
container_volume |
168 |
container_issue |
10 |
container_start_page |
1132 |
op_container_end_page |
1139 |
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1766041489117282304 |