Midlife physical activity preserves lower extremity function in older adults: age gene/environment susceptibility-Reykjavik study

OBJECTIVES: To examine the long-term association between midlife physical activity (PA) and lower extremity function (LEF) in late life. DESIGN: Longitudinal study with an average of 25 years of follow-up. SETTING: Community-dwelling old population in Reykjavik, Iceland. PARTICIPANTS: Four thousand...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society
Main Authors: Chang, Milan, Saczynski, Jane S., Snaedal, Jon, Bjornsson, Sigurbjorn, Einarsson, Bjorn, Garcia, Melissa E., Aspelund, Thor, Siggeirsdottir, Kristine, Gudnason, Vilmundur, Launer, Lenore J., Harris, Tamara B., Jonsson, Palmi V.
Other Authors: Meyers Primary Care Institute, Department of Medicine, Division of Geriatric Medicine
Format: Article in Journal/Newspaper
Language:English
Published: 2022
Subjects:
Aged
Aging
Cognition Disorders
Environmental Exposure
Female
Forecasting
*Genetic Predisposition to Disease
*Geriatric Assessment
Humans
Iceland
Lower Extremity
Male
Morbidity
Motor Activity
Geriatrics
Health Services Research
Primary Care
Online Access:https://doi.org/10.1111/jgs.12077
https://hdl.handle.net/20.500.14038/37226
https://escholarship.umassmed.edu/meyers_pp/643
Description
Summary:OBJECTIVES: To examine the long-term association between midlife physical activity (PA) and lower extremity function (LEF) in late life. DESIGN: Longitudinal study with an average of 25 years of follow-up. SETTING: Community-dwelling old population in Reykjavik, Iceland. PARTICIPANTS: Four thousand seven hundred fifty-three community-dwelling men and women (mean age 76 +/- 6) in Reykjavik, Iceland. MEASUREMENTS: On the basis of weekly hours of regular PA reported at the midlife examination, participants were classified as active or inactive. Measures of LEF in late life were gait speed on a 6-m walk, Timed Up and Go (TUG), and knee extension (KE) strength tests. Linear regression analysis was used to examine the association. RESULTS: Participants who were active in midlife had significantly better LEF (faster gait speed, beta = 0.50, P CONCLUSION: Regular PA in midlife is associated with better performance of LEF in later life, even after controlling for late-life cognitive function. Geriatrics Society.

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