The corticotropin-releasing hormone binding protein is associated with major depression in a population from northern Sweden

Background: Recent research suggests that central corticotropin releasing hormone hyperdrive is an important neurobiological risk factor for developing major depression. The availability of free corticotropin releasing hormone in the central nervous system is tightly regulated by the expression of c...

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Bibliographic Details
Main Authors: Claes, Stephan, Villafuerte, S, Forsgren, T, Sluijs, S, Del-Favero, J, Adolfsson, R, Van Broeckhoven, C
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier science inc 2003
Subjects:
crh binding protein
crh
major depression
hpa axis
pituitary-adrenal axis
high familial risk
haplotype frequencies
affective-disorders
crh test
dsm-iv
childhood
responses
stress
abuse
Northern Sweden
Online Access:https://lirias.kuleuven.be/handle/123456789/161523
http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=PRODUCT_NAME&KeyAID=10.1016%2FS0006-3223%2803%2900425-6&DestApp=DOI&SrcAppSID=APP_SID&SrcJTitle=WURS_TITLE
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Summary:Background: Recent research suggests that central corticotropin releasing hormone hyperdrive is an important neurobiological risk factor for developing major depression. The availability of free corticotropin releasing hormone in the central nervous system is tightly regulated by the expression of corticotropin releasing hormone binding protein. Therefore, the gene encoding for corticotropin releasing hormone binding protein is a functional candidate gene for major depression. status: published

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