Colonization and adaptation patterns of the house mouse (Mus musculus domesticus) on the Kerguelen Archipelago
Starting from Western Europe, the house mouse (Mus musculus domesticus) has spread across the globe in historic times. However, most of the southern oceanic islands were colonized by mice only within the past 300 years. This makes them an excellent model for studying the evolutionary processes durin...
| Main Author: | |
|---|---|
| Other Authors: | , |
| Format: | Doctoral or Postdoctoral Thesis |
| Language: | English |
| Published: |
2011
|
| Subjects: | |
| Online Access: | https://nbn-resolving.org/urn:nbn:de:gbv:8-diss-61247 https://macau.uni-kiel.de/receive/diss_mods_00006124 https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00003614/Thesis_Hardouin.pdf |
| Summary: | Starting from Western Europe, the house mouse (Mus musculus domesticus) has spread across the globe in historic times. However, most of the southern oceanic islands were colonized by mice only within the past 300 years. This makes them an excellent model for studying the evolutionary processes during early stages of new colonization and for understanding mechanisms of early adaptation. Twenty-four microsatellite loci and the mitochondrial D-loop sequence were typed in a total of 534 mice mainly from the Kerguelen Archipelago but also from Falkland Islands, Marion Island, Amsterdam Island, Antipodes Island, Macquarie Island, Auckland Islands, and one sample from South Georgia. Although there was heavy ship traffic for over a hundred years to the Kerguelen Archipelago, it appears that only the mice that have arrived first have colonized the main island (Grande Terre) and most of the associated small islands indeed mice shared the same D-loop haplotype as well as the same Y chromosomal haplotype. The second mice invasion has occurred on islands that are detached from Grande Terre (Cimetière Island and Cochons Island) and were likely to have had no resident mice prior to their arrival. They displayed a different mitochondrial D-loop haplotype and were genetically distinct in the autosomes. However, the Y chromosome haplotype was related to the one found in Grande Terre, suggesting that they came from a related source population. These data suggest that an area colonized by mice is refractory to further introgression, possibly due to fast adaptations of the resident mice to local conditions. Interestingly, single step mutational derivatives of one of the major mitochondrial haplotypes were found several times in different southern hemisphere islands, suggesting an unusually high mutation rate or the putative presence of a selective sweep in the mitochondrial genome. In order to investigate further the genetic basis of adaptation on southern hemisphere islands a genome-wide microsatellite screen for selective sweeps ... |
|---|