Unexpected enzyme-catalyzed regioselective acylation of flavonoid aglycones and rapid product screening

Unprecedented regioselective acylation of flavonoid aglycones was achieved using Candida antarctica lipase B (CALB). The rapid screening of product formation was performed by the use of the high resolution phenol-type OH H-1 NMR spectral region recorded after the addition of picric acid. Organic and...

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Bibliographic Details
Main Authors: Kyriakou, E., Primikyri, A., Charisiadis, P., Katsoura, M., Gerothanassis, I. P., Stamatis, H., Tzakos, A. G.
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry 2012
Subjects:
human leukemia-cells
candida-antarctica
quercetin acetylation
natural-products
lipase
derivatives
inhibitors
insights
media
death
Antarc*
Antarctica
Online Access:http://olympias.lib.uoi.gr/jspui/handle/123456789/9805
Description
Summary:Unprecedented regioselective acylation of flavonoid aglycones was achieved using Candida antarctica lipase B (CALB). The rapid screening of product formation was performed by the use of the high resolution phenol-type OH H-1 NMR spectral region recorded after the addition of picric acid. Organic and Biomolecular Chemistry

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