Possible role of calcitonin gene-related peptide in osmoregulation via the endocrine control of the gill in a teleost, the eel, Anguilla anguilla

Osmoregulation is a major challenge in aquatic animals involving a complex endocrine control. We investigated the potential role of calcitonin gene-related peptide (CGRP, a neuromediator in mammals) in the endocrine control of the gill in a teleost, the eel. Transfer from freshwater to seawater indu...

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Bibliographic Details
Main Authors: Lafont, Anne-Gaelle, Fitzpatrick, Thomas, Rankin, J. Cliff, Dufour, Sylvie, Fouchereau-Peron, Martine
Format: Article in Journal/Newspaper
Language:unknown
Published: Elsevier 2006
Subjects:
Q Science (General)
QH301 Biology
QH426 Genetics
Anguilla anguilla
Online Access:http://eprints.hud.ac.uk/id/eprint/575/
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0M-4HDG92S-2&_user=495973&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000024198&_version=1&_urlVersion=0&_userid=495973&md5=fed6ed9630136e94bfc9ecf1a6d00dbe
Description
Summary:Osmoregulation is a major challenge in aquatic animals involving a complex endocrine control. We investigated the potential role of calcitonin gene-related peptide (CGRP, a neuromediator in mammals) in the endocrine control of the gill in a teleost, the eel. Transfer from freshwater to seawater induced an hyperosmolality and a concomitant large increase in plasma CGRP levels. Specific CGRP binding sites were characterized in the gill and their number was up-regulated after seawater transfer. This study suggests that the endocrine control of gill function during osmoregulation may represent an ancient role of CGRP in vertebrates.

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