A secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction?

One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is stil...

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Bibliographic Details
Published in:Angewandte Chemie International Edition
Main Authors: Haselhorst, T, Lai, JCC, Garcia, JM, Dyason, JC, Böhm, R, Madge, PD, Rose, FJ, von Itzstein, M, Peiris, JSM, Nicholls, JM
Format: Article in Journal/Newspaper
Language:English
Published: Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home 2012
Subjects:
Neuraminidase - chemistry - metabolism
Nuclear Magnetic Resonance
Biomolecular
Orthomyxoviridae - chemistry - enzymology
Oseltamivir - pharmacology
N-Acetylneuraminic Acid - metabolism
Avian flu
Online Access:https://doi.org/10.1002/anie.201108245
http://hdl.handle.net/10722/148687
Description
Summary:One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. link_to_subscribed_fulltext

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