Highly pathogenic avian influenza A(H5N1) virus infection in foxes with PB2-M535I identified as a novel mammalian adaptation, Northern Ireland, July 2023

We report cases of mammalian infection with highly pathogenic avian influenza (HPAI) virus A(H5N1) clade 2.3.4.4b in Northern Ireland. Two common gulls (Larus canus) and two red fox kits (Vulpes vulpes), were found dead in close vicinity. Comparison of viral whole genome sequences obtained from the...

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Bibliographic Details
Main Authors: Lagan, Paula, Mckenna, Robyn, Baleed, Salam, Hanna, Bob, Barley, Jason, Mcconnell, Shirley, Georgaki, Anastasia, Sironen, Tarja, Kauppinen, Ari, Gadd, Tuija, Lindh, Erika, Ikonen, Niina, McMenamy, Michael J., Lemon, Ken
Other Authors: Helsinki One Health (HOH), Viral Zoonosis Research Unit, Emerging Infections Research Group, Department of Virology, Veterinary Biosciences, Medicum
Format: Article in Journal/Newspaper
Language:English
Published: CENTRE EUROPEEN POUR LA SURVEILLANCE EPIDEMIOLOGIQUE DU SIDA 2023
Subjects:
413 Veterinary science
Larus canus
Online Access:http://hdl.handle.net/10138/568778
Description
Summary:We report cases of mammalian infection with highly pathogenic avian influenza (HPAI) virus A(H5N1) clade 2.3.4.4b in Northern Ireland. Two common gulls (Larus canus) and two red fox kits (Vulpes vulpes), were found dead in close vicinity. Comparison of viral whole genome sequences obtained from the animals identified a novel mammalian adaptation, PB2-M535I. Analysis of genetic sequences from other recent mammalian infections shows that this mutation has arisen on at least five occasions in three European countries since April 2023. Peer reviewed

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