Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish
Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the com...
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ftunivgent:oai:archive.ugent.be:8606207 2023-06-11T04:10:19+02:00 Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish Suniaga, Santiago Rolvien, Tim vom Scheidt, Annika Fiedler, Imke AK Bale, Hrishikesh A Huysseune, Ann Witten, Paul Eckhard Amling, Michael Busse, Bjoern 2018 application/pdf https://biblio.ugent.be/publication/8606207 http://hdl.handle.net/1854/LU-8606207 https://doi.org/10.1038/s41598-018-21776-1 https://biblio.ugent.be/publication/8606207/file/8619440 eng eng https://biblio.ugent.be/publication/8606207 http://hdl.handle.net/1854/LU-8606207 http://dx.doi.org/10.1038/s41598-018-21776-1 https://biblio.ugent.be/publication/8606207/file/8619440 Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) info:eu-repo/semantics/openAccess SCIENTIFIC REPORTS ISSN: 2045-2322 Biology and Life Sciences MULTIPLE LENGTH-SCALES BREAM SPARUS-AURATA HUMAN CORTICAL BONE PHENOTYPIC PLASTICITY DENSITY DISTRIBUTION ATLANTIC SALMON VERTEBRAL BONE TELEOST FISH DANIO-RERIO CELLS journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2018 ftunivgent https://doi.org/10.1038/s41598-018-21776-1 2023-05-10T22:36:59Z Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, bone volume and mineralization. Clearly, modeling processes in zebrafish bone resemble processes in human bone. This study highlights how exercise experiments in adult zebrafish foster in-depth insight into aging-related bone diseases and can thus catalyze the search for appropriate prevention and new treatment options. Article in Journal/Newspaper Atlantic salmon Ghent University Academic Bibliography Scientific Reports 8 1 |
institution |
Open Polar |
collection |
Ghent University Academic Bibliography |
op_collection_id |
ftunivgent |
language |
English |
topic |
Biology and Life Sciences MULTIPLE LENGTH-SCALES BREAM SPARUS-AURATA HUMAN CORTICAL BONE PHENOTYPIC PLASTICITY DENSITY DISTRIBUTION ATLANTIC SALMON VERTEBRAL BONE TELEOST FISH DANIO-RERIO CELLS |
spellingShingle |
Biology and Life Sciences MULTIPLE LENGTH-SCALES BREAM SPARUS-AURATA HUMAN CORTICAL BONE PHENOTYPIC PLASTICITY DENSITY DISTRIBUTION ATLANTIC SALMON VERTEBRAL BONE TELEOST FISH DANIO-RERIO CELLS Suniaga, Santiago Rolvien, Tim vom Scheidt, Annika Fiedler, Imke AK Bale, Hrishikesh A Huysseune, Ann Witten, Paul Eckhard Amling, Michael Busse, Bjoern Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish |
topic_facet |
Biology and Life Sciences MULTIPLE LENGTH-SCALES BREAM SPARUS-AURATA HUMAN CORTICAL BONE PHENOTYPIC PLASTICITY DENSITY DISTRIBUTION ATLANTIC SALMON VERTEBRAL BONE TELEOST FISH DANIO-RERIO CELLS |
description |
Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, bone volume and mineralization. Clearly, modeling processes in zebrafish bone resemble processes in human bone. This study highlights how exercise experiments in adult zebrafish foster in-depth insight into aging-related bone diseases and can thus catalyze the search for appropriate prevention and new treatment options. |
format |
Article in Journal/Newspaper |
author |
Suniaga, Santiago Rolvien, Tim vom Scheidt, Annika Fiedler, Imke AK Bale, Hrishikesh A Huysseune, Ann Witten, Paul Eckhard Amling, Michael Busse, Bjoern |
author_facet |
Suniaga, Santiago Rolvien, Tim vom Scheidt, Annika Fiedler, Imke AK Bale, Hrishikesh A Huysseune, Ann Witten, Paul Eckhard Amling, Michael Busse, Bjoern |
author_sort |
Suniaga, Santiago |
title |
Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish |
title_short |
Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish |
title_full |
Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish |
title_fullStr |
Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish |
title_full_unstemmed |
Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish |
title_sort |
increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish |
publishDate |
2018 |
url |
https://biblio.ugent.be/publication/8606207 http://hdl.handle.net/1854/LU-8606207 https://doi.org/10.1038/s41598-018-21776-1 https://biblio.ugent.be/publication/8606207/file/8619440 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
SCIENTIFIC REPORTS ISSN: 2045-2322 |
op_relation |
https://biblio.ugent.be/publication/8606207 http://hdl.handle.net/1854/LU-8606207 http://dx.doi.org/10.1038/s41598-018-21776-1 https://biblio.ugent.be/publication/8606207/file/8619440 |
op_rights |
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41598-018-21776-1 |
container_title |
Scientific Reports |
container_volume |
8 |
container_issue |
1 |
_version_ |
1768384662516793344 |