Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish

Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the com...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Suniaga, Santiago, Rolvien, Tim, vom Scheidt, Annika, Fiedler, Imke AK, Bale, Hrishikesh A, Huysseune, Ann, Witten, Paul Eckhard, Amling, Michael, Busse, Bjoern
Format: Article in Journal/Newspaper
Language:English
Published: 2018
Subjects:
Biology and Life Sciences
MULTIPLE LENGTH-SCALES
BREAM SPARUS-AURATA
HUMAN CORTICAL BONE
PHENOTYPIC PLASTICITY
DENSITY DISTRIBUTION
ATLANTIC SALMON
VERTEBRAL
BONE
TELEOST FISH
DANIO-RERIO
CELLS
Atlantic salmon
Online Access:https://biblio.ugent.be/publication/8606207
http://hdl.handle.net/1854/LU-8606207
https://doi.org/10.1038/s41598-018-21776-1
https://biblio.ugent.be/publication/8606207/file/8619440
Description
Summary:Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, bone volume and mineralization. Clearly, modeling processes in zebrafish bone resemble processes in human bone. This study highlights how exercise experiments in adult zebrafish foster in-depth insight into aging-related bone diseases and can thus catalyze the search for appropriate prevention and new treatment options.

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