Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway

Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a na...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Asselman, Jana, Van Acker, Emmanuel, De Rijcke, Maarten, Tilleman, Laurentijn, Van Nieuwerburgh, Filip, Mees, Jan, De Schamphelaere, Karel, Janssen, Colin
Format: Article in Journal/Newspaper
Language:English
Published: 2019
Subjects:
Biology and Life Sciences
Earth and Environmental Sciences
HARMFUL ALGAL BLOOMS
HUMAN HEALTH
DIFFERENTIAL EXPRESSION
BIOCONDUCTOR PACKAGE
ARCTIC-OCEAN
SYSTEM
TOXINS
CELLS
WELL
BREVETOXINS
Arctic
Arctic Ocean
Human health
Online Access:https://biblio.ugent.be/publication/8594007
http://hdl.handle.net/1854/LU-8594007
https://doi.org/10.1038/s41598-018-36866-3
https://biblio.ugent.be/publication/8594007/file/8594008
Description
Summary:Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a natural sea spray aerosol collected at the seashore in Belgium, a laboratory-generated SSA, the marine algal toxin homoyessotoxin and a chemical inhibitor of the mammalian target of rapamycin (mTOR) pathway. We observed significant increased expression of genes related to the mTOR pathway and Proprotein convertase subtilisin/kexin type 9 (PCSK9) after exposure to homoyessotoxin and the laboratory-generated SSA. In contrast, we observed a significant decrease in gene expression in the mTOR pathway and of PCSK9 after exposure to the natural SSA and the mTOR inhibitor, suggesting induction of apoptosis. Our results indicate that marine biogenics in SSAs interact with PCSK9 and the mTOR pathway and can be used in new potential pharmaceutical applications. Overall, our results provide a substantial molecular evidence base for potential beneficial health effects at environmentally relevant concentrations of natural SSAs.

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