Protein-derived bioactives affecting CCK-induced satiety: how to detect untargeted compounds and determine their identity

• Main Authors: Staljanssens, Dorien, Smagghe, Guy, Van Camp, John
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2012
• Subjects: Biology and Life Sciences; satiety; Cholecystokinin; bioactive peptides; protein hydrolysates; CCK1 receptor; COD GADUS-MORHUA; FOOD-INTAKE; CHOLECYSTOKININ SECRETION; STC-1 CELLS; RELEASE; APPETITE; HUMANS; EXPRESSION; PRODUCTS; FISH; Gadus morhua
• Online Access: https://biblio.ugent.be/publication/2122228; http://hdl.handle.net/1854/LU-2122228; https://biblio.ugent.be/publication/2122228/file/6771211

Cholecystokinin (CCK) is a gut hormone that induces a feeling of satiety and therefore plays an important role in weight regulation. In this minireview, different food proteins and protein hydrolysates will be introduced that are able to enhance CCK-mediated satiety. This mechanism can be influenced at three interaction points, namely CCK release, trypsin-sensitive luminal CCK-releasing factors and the CCK receptor. Food components able to affect satiety are very promising ingredients in the development of functional foods that can be used as an aid in the battle against obesity.