Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#

Three new dimeric polyketides, i.e., phaeochromycins I–K ( 1 – 3 , respectively) and a known polyketide phaeochromycin F ( 4 ), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimens...

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Bibliographic Details
Main Authors: Yibo Xu (1763989), Dongyang Wang (134365), Qianqian Lv (3840769), Peng Fu (417962), Ying Wang (11406), Weiming Zhu (391049)
Format: Other Non-Article Part of Journal/Newspaper
Language:unknown
Published: 2022
Subjects:
Biochemistry
Medicine
Ecology
Hematology
Plant Biology
Virology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
selective antiproliferative activity
hucct1 cell lines
bridged dimeric polyketides
3 </ b
2 </ b
e .
phaeochromycins
50 </ sub
streptomyces </
– k
values ranging
three methylene
hresims data
exhibiting ic
culture broth
analyzing one
52 μm
permafrost
Online Access:https://doi.org/10.1021/acsomega.2c07038.s001
Description
Summary:Three new dimeric polyketides, i.e., phaeochromycins I–K ( 1 – 3 , respectively) and a known polyketide phaeochromycin F ( 4 ), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimensional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC 50 values ranging from 8.83 to 10.52 μM.

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