Efeito do extrato aquoso de Allium sativum L. sobre parâmetros bioquímicos de ratas com diabete induzido por Streptozotocin

• Main Authors: Kiss, A. C I, Takaku, M., Damasceno, D. C., Campos, K. E., Sinzato, Y. K., Lima, P. O., Volpato, G. T.
• Other Authors: Universidade Estadual Paulista (UNESP)
• Format: Article in Journal/Newspaper
• Language: Portuguese
• Published: 2006
• Subjects: Allium sativum; Diabetes; Garlic; Hypoglycemic; Medicinal plants; Mellitus experimental; Rats winstar; Streptozotocin; garlic extract; triacylglycerol; very low density lipoprotein; animal experiment; animal model; controlled study; drug activity; drug effect; drug mechanism; female; glucose blood level; glycogen liver level; nonhuman; rat; streptozocin diabetes; triacylglycerol blood level; Animalia; Rattus; Rattus norvegicus; Rattus rattus
• Online Access: http://hdl.handle.net/11449/68909; http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo4_v8_n3.pdf

Many plants, even without scientific confirmation, are used in Brazil as hypoglycemic. The objective of the present work was to study the influence of the Allium sativum treatment, plant known popularly as garlic, on characteristic biochemical parameters in streptozotocin-induced diabetic rats. Female Wistar rats were injected with 40 mg kg-1 streptozotocin (STZ). Oral administration of an aqueous extract of A. sativum was given to the diabetic animals in 2 doses: 200 and 400 mg kg-1 (n=6 animals/group). Diabetic rats given distilled water constituted the control group. After 28 days of treatment, the female rats were anesthetized and died by decapitation for collection of the blood for biochemical determinations and retreat of liver samples for hepatic glycogen dosage. The treatment with Allium sativum in the doses of 200 and 400 mg kg-1 alter no concentrations of total proteins, hepatic glycogen, triglycerides and VLDL, but it promoted reduction in the total cholesterol rate (control=280.5 ± 30.9; 200 mg kg-1 A. sativum =169.9 ± 19.5 and 400 mg kg-1 A. sativum =148.4 ± 26.6 mg dL-1) and LDL (control=128.8± 25.3; 200 mg kg-1 A. sativum = 41.4 ± 16.2 and 400 mg kg-1 A. sativum=42.0 ± 26.0 mg dL-1). The extract presented beneficial effect because it decreased 13.0% of glycemia in the highest dose. Therefore, the of garlic extract reduced the HDL concentration in two tested doses (control= 81.4 ± 30.2; 200 mg kg-1 A. sativum=49.6 ± 14.3 and 400 mg kg-1 A. sativum=41.7 ± 16.1 mg dL -1), presenting impaired effect. Thus, the garlic extract showed efficiency in the analyzed experimental conditions, and it could be used as complementary therapy to diabetic patients.