Enantioselective enzymatic modification of chiral block copolymers
Block copolymers comprising blocks with pendant hydroxy groups of opposite chirality are synthesized by RAFT polymn. of (R)- and (S)-1-(4-vinylphenyl)ethanol (1R and 1S) as monomers. Initially, poly(styrene) macro-RAFT agents are chain-extended with both enantiomeric monomers to obtain poly(styrene-...
Published in: | Macromolecular Chemistry and Physics |
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Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2013
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Subjects: | |
Online Access: | https://research.tue.nl/en/publications/e2fc7435-edf1-4532-a521-8abccdd0344b https://doi.org/10.1002/macp.201200633 |
Summary: | Block copolymers comprising blocks with pendant hydroxy groups of opposite chirality are synthesized by RAFT polymn. of (R)- and (S)-1-(4-vinylphenyl)ethanol (1R and 1S) as monomers. Initially, poly(styrene) macro-RAFT agents are chain-extended with both enantiomeric monomers to obtain poly(styrene-b-1R) and poly(styrene-b-1S) with controlled mol. wt. and low polydispersities. Enantioselective esterification with vinyl acetate by Candida Antarctica Lipase B (CALB) is only possible on the 1R-contg. block copolymer. This concept is extended to a series of chiral block copolymers poly(1R-b-1S) which, apart from their optical rotation, all behave like very similar homopolymers. By enzymic enantioselective esterification on the 1R-block, block copolymer structures were obtained. |
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