Mutation in a SARS-CoV-2 haplotype from sub-Antarctic Chile reveals new insights into the spike’s dynamics

The emergence of SARS-CoV-2 variants, as observed with the D614G spike protein mutant and, more recently, with B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1) lineages, represent a continuous threat and might lead to strains of higher infectivity and/or virulence. We report on the occurren...

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Bibliographic Details
Published in:Viruses
Main Authors: González Puelma, Jorge, Aldridge, Jacqueline, Montes de Oca, Marco, Pinto, Mónica, Uribe Paredes, Roberto, Fernández Goycoolea, José, Álvarez Saravia, Diego, Álvarez, Hermy, Encina, Gonzalo, Weitzel, Thomas, Muñoz, Rodrigo, Olivera Nappa, Alvaro María, Pantano, Sergio, Navarrete, Marcelo A.
Format: Article in Journal/Newspaper
Language:English
Published: MDPI 2021
Subjects:
SARS-CoV2
Variant
Covid19
COVID-19 (Enfermedad)
Antarctic
Magallanes
Pasteur
The Spike
Antarc*
Online Access:https://doi.org/10.3390/v13050883
https://repositorio.uchile.cl/handle/2250/183468
Description
Summary:The emergence of SARS-CoV-2 variants, as observed with the D614G spike protein mutant and, more recently, with B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1) lineages, represent a continuous threat and might lead to strains of higher infectivity and/or virulence. We report on the occurrence of a SARS-CoV-2 haplotype with nine mutations including D614G/T307I double-mutation of the spike. This variant expanded and completely replaced previous lineages within a short period in the subantarctic Magallanes Region, southern Chile. The rapid lineage shift was accompanied by a significant increase of cases, resulting in one of the highest incidence rates worldwide. Comparative coarse-grained molecular dynamic simulations indicated that T307I and D614G belong to a previously unrecognized dynamic domain, interfering with the mobility of the receptor binding domain of the spike. The T307I mutation showed a synergistic effect with the D614G. Continuous surveillance of new mutations and molecular analyses of such variations are important tools to understand the molecular mechanisms defining infectivity and virulence of current and future SARS-CoV-2 strains. Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1180882 FOCEM (MERCOSUR Structural Convergence Fund) COF 03/11 "URGENCE COVID-19" fundraising campaign of Institut Pasteur MAG1895 Versión publicada - versión final del editor

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