Ancient human genome sequence of an extinct Palaeo-Eskimo
No We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an...
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Online Access: | http://hdl.handle.net/10454/6149 https://doi.org/10.1038/nature08835 |
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ftunivbradford:oai:bradscholars.brad.ac.uk:10454/6149 2024-04-21T08:01:35+00:00 Ancient human genome sequence of an extinct Palaeo-Eskimo Rasmussen, M. Li, Y. Lindgreen, S. Pedersen, J.S. Albrechtsen, A. Moltke, I. Metspalu, M. Metspalu, E. Kivisild, T. Gupta, R. Bertalan, M. Nielsen, K. Gilbert, M.T.P. Wang, Y. Raghavan, M. Campos, P.F. Kamp, H.M. Wilson, Andrew S. Gledhill, Andrew R. Tridico, S. Bunce, M. Lorenzen, E.D. Binladen, J. Guo, X. Zhao, J. Zhang, X. Zhang, H. Li, Z. Chen, M. Orlando, L. Kristiansen, K. Bak, M. Tommerup, N. Bendixen, C. Pierre, T.L. Gronnow, B. Meldgaard, M. Andreasen, C. Fedorova, S.A. Osipova, L.P. Higham, T.F.G. Ramsey, C.B. Hansen, T.v.O. Nielsen, F.C. Crawford, M.H. Brunak, S. Sicheritz-Ponten, T. Villems, R. Nielsen, R. Krogh, A. Wang, J. Willerslev, E. 2010 http://hdl.handle.net/10454/6149 https://doi.org/10.1038/nature08835 unknown Rasmussen M, Li Y, Lindgreen ST et al (2010) Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature. 463(7282): 757-62. http://hdl.handle.net/10454/6149 https://doi.org/10.1038/nature08835 Cryopreservation Emigration Immigration Extinction Genetics Population Genome Human Genomics Genotype Greenland Hair History Ancient Humans Inuits Male Phenotype Phylogeny Polymorphism Single nucleotide Sequence analysis DNA Siberia Ethnology REF 2014 Article No full-text in the repository 2010 ftunivbradford https://doi.org/10.1038/nature08835 2024-03-27T15:40:00Z No We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. Article in Journal/Newspaper eskimo* Greenland inuit inuits permafrost Siberia Bradford Scholars@University of Bradford Nature 463 7282 757 762 |
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Open Polar |
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Bradford Scholars@University of Bradford |
op_collection_id |
ftunivbradford |
language |
unknown |
topic |
Cryopreservation Emigration Immigration Extinction Genetics Population Genome Human Genomics Genotype Greenland Hair History Ancient Humans Inuits Male Phenotype Phylogeny Polymorphism Single nucleotide Sequence analysis DNA Siberia Ethnology REF 2014 |
spellingShingle |
Cryopreservation Emigration Immigration Extinction Genetics Population Genome Human Genomics Genotype Greenland Hair History Ancient Humans Inuits Male Phenotype Phylogeny Polymorphism Single nucleotide Sequence analysis DNA Siberia Ethnology REF 2014 Rasmussen, M. Li, Y. Lindgreen, S. Pedersen, J.S. Albrechtsen, A. Moltke, I. Metspalu, M. Metspalu, E. Kivisild, T. Gupta, R. Bertalan, M. Nielsen, K. Gilbert, M.T.P. Wang, Y. Raghavan, M. Campos, P.F. Kamp, H.M. Wilson, Andrew S. Gledhill, Andrew R. Tridico, S. Bunce, M. Lorenzen, E.D. Binladen, J. Guo, X. Zhao, J. Zhang, X. Zhang, H. Li, Z. Chen, M. Orlando, L. Kristiansen, K. Bak, M. Tommerup, N. Bendixen, C. Pierre, T.L. Gronnow, B. Meldgaard, M. Andreasen, C. Fedorova, S.A. Osipova, L.P. Higham, T.F.G. Ramsey, C.B. Hansen, T.v.O. Nielsen, F.C. Crawford, M.H. Brunak, S. Sicheritz-Ponten, T. Villems, R. Nielsen, R. Krogh, A. Wang, J. Willerslev, E. Ancient human genome sequence of an extinct Palaeo-Eskimo |
topic_facet |
Cryopreservation Emigration Immigration Extinction Genetics Population Genome Human Genomics Genotype Greenland Hair History Ancient Humans Inuits Male Phenotype Phylogeny Polymorphism Single nucleotide Sequence analysis DNA Siberia Ethnology REF 2014 |
description |
No We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. |
format |
Article in Journal/Newspaper |
author |
Rasmussen, M. Li, Y. Lindgreen, S. Pedersen, J.S. Albrechtsen, A. Moltke, I. Metspalu, M. Metspalu, E. Kivisild, T. Gupta, R. Bertalan, M. Nielsen, K. Gilbert, M.T.P. Wang, Y. Raghavan, M. Campos, P.F. Kamp, H.M. Wilson, Andrew S. Gledhill, Andrew R. Tridico, S. Bunce, M. Lorenzen, E.D. Binladen, J. Guo, X. Zhao, J. Zhang, X. Zhang, H. Li, Z. Chen, M. Orlando, L. Kristiansen, K. Bak, M. Tommerup, N. Bendixen, C. Pierre, T.L. Gronnow, B. Meldgaard, M. Andreasen, C. Fedorova, S.A. Osipova, L.P. Higham, T.F.G. Ramsey, C.B. Hansen, T.v.O. Nielsen, F.C. Crawford, M.H. Brunak, S. Sicheritz-Ponten, T. Villems, R. Nielsen, R. Krogh, A. Wang, J. Willerslev, E. |
author_facet |
Rasmussen, M. Li, Y. Lindgreen, S. Pedersen, J.S. Albrechtsen, A. Moltke, I. Metspalu, M. Metspalu, E. Kivisild, T. Gupta, R. Bertalan, M. Nielsen, K. Gilbert, M.T.P. Wang, Y. Raghavan, M. Campos, P.F. Kamp, H.M. Wilson, Andrew S. Gledhill, Andrew R. Tridico, S. Bunce, M. Lorenzen, E.D. Binladen, J. Guo, X. Zhao, J. Zhang, X. Zhang, H. Li, Z. Chen, M. Orlando, L. Kristiansen, K. Bak, M. Tommerup, N. Bendixen, C. Pierre, T.L. Gronnow, B. Meldgaard, M. Andreasen, C. Fedorova, S.A. Osipova, L.P. Higham, T.F.G. Ramsey, C.B. Hansen, T.v.O. Nielsen, F.C. Crawford, M.H. Brunak, S. Sicheritz-Ponten, T. Villems, R. Nielsen, R. Krogh, A. Wang, J. Willerslev, E. |
author_sort |
Rasmussen, M. |
title |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_short |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_fullStr |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full_unstemmed |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_sort |
ancient human genome sequence of an extinct palaeo-eskimo |
publishDate |
2010 |
url |
http://hdl.handle.net/10454/6149 https://doi.org/10.1038/nature08835 |
genre |
eskimo* Greenland inuit inuits permafrost Siberia |
genre_facet |
eskimo* Greenland inuit inuits permafrost Siberia |
op_relation |
Rasmussen M, Li Y, Lindgreen ST et al (2010) Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature. 463(7282): 757-62. http://hdl.handle.net/10454/6149 https://doi.org/10.1038/nature08835 |
op_doi |
https://doi.org/10.1038/nature08835 |
container_title |
Nature |
container_volume |
463 |
container_issue |
7282 |
container_start_page |
757 |
op_container_end_page |
762 |
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1796941725097263104 |