A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats

Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Ramsvik, Marie Sannes, Bjørndal, Bodil, Bruheim, Inge, Bohov, Pavol, Berge, Rolf Kristian
Format: Article in Journal/Newspaper
Language:English
Published: MDPI 2016
Subjects:
Antarctic krill
lipogenesis
plasma lipids
Inflammation
antioxidant capacity
Omega-3 polyunsaturated fatty acids
cholesterol
lipid lowering
VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811
VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811
Antarctic
Antarc*
Antarctic Krill
Online Access:https://hdl.handle.net/1956/12496
https://doi.org/10.3390/md13074375
Description
Summary:Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2). Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2) was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. publishedVersion

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