Do neutral amino acids and their N-methylated analogues share the same Na-dependent carrier in brush-border membrane from the eel intestine?

1. 1. Kinetics of Na-neutral amino acid cotransport by brush-border membrane vesicles from the eel (Anguilla anguilla) intestine was studied. 2. 2. The substrate-dependent Na-influx was estimated by monitoring the decay of a preset inside negative membrane potential with a voltage-sensitive fluoresc...

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Bibliographic Details
Published in:Comparative Biochemistry and Physiology Part A: Physiology
Main Authors: CASSANO, Giuseppe, Maffia, M, Ramires, P. A, Vilella, S, Storelli, C.
Other Authors: Cassano, Giuseppe
Format: Article in Journal/Newspaper
Language:English
Published: 1990
Subjects:
amino acid transport
animal cell
article
brush border vesicle
fish
intestine
nonhuman
priority journal
sodium transport
Anguilla anguilla
Online Access:http://hdl.handle.net/11586/140353
https://doi.org/10.1016/0300-9629(90)90035-Q
Description
Summary:1. 1. Kinetics of Na-neutral amino acid cotransport by brush-border membrane vesicles from the eel (Anguilla anguilla) intestine was studied. 2. 2. The substrate-dependent Na-influx was estimated by monitoring the decay of a preset inside negative membrane potential with a voltage-sensitive fluorescent dye. 3. 3. N-Methylglycine, N-methylalanine and α-(methylamino)-isobutyric acid are transported by the Na-dependent carrier responsible for proline translocation. This carrier is distinct from the one responsible for glycine, alanine and α-aminoisobutyric acid translocation.

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