Current challenges in protein engineering

Proteins are the molecular tools of life and men have sought ways to adapt them to meet their needs. The aim of this text is to present the scientific grounds about proteins such as their structural levels, folding, catalytic activity of enzymes, and limitations of their applications due to their na...

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Bibliographic Details
Published in:CIENCIA ergo sum
Main Author: Jiménez Rosales, Angélica
Format: Article in Journal/Newspaper
Language:Spanish
Published: Universidad Autónoma del Estado de México 2019
Subjects:
Online Access:https://cienciaergosum.uaemex.mx/article/view/10899
https://doi.org/10.30878/ces.v26n3a9
Description
Summary:Proteins are the molecular tools of life and men have sought ways to adapt them to meet their needs. The aim of this text is to present the scientific grounds about proteins such as their structural levels, folding, catalytic activity of enzymes, and limitations of their applications due to their nature. The conceptual and methodological bases of protein engineering are illustrated, in a simplified manner, including the scope and future perspectives towards the advance of science and innovation of processes. It is concluded that protein engineering is a field which continues to implement computational and genetic-proteomic engineering tools, through which new proteins can be generated to expand their applications in different processes. Las proteínas son la maquinaria molecular que sustenta la vida, y el hombre ha buscado adaptarlas para resolver sus necesidades. En esta revisión, se presentan los fundamentos sobre las proteínas, sus niveles estructurales, plegamiento, las enzimas y su actividad catalítica y las limitantes de sus aplicaciones debido a su naturaleza. De manera simplificada, se ilustran las bases conceptuales y metodológicas de la ingeniería de proteínas, su alcance y las perspectivas de su aplicación en la ciencia y la innovación de procesos. Se concluye que la ingeniería de proteínas es una rama que continúa implementando herramientas computacionales e ingeniería gen´ética-proteómica por medio de la cual es posible la generación de nuevas proteínas para ampliar sus aplicaciones en diversos procesos.