Variolins and related alkaloids

• Published in: Chemical Reviews
• Main Authors: Walker, S., Carter, E., Huff, B., Morris, J.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Amer Chemical Soc 2009
• Subjects: Aza Compounds; Indole Alkaloids; Pyrimidines; Cyclin-Dependent Kinases; Antineoplastic Agents; Bridged Bicyclo Compounds; Heterocyclic; Antarctic; Hernandez; Palermo; The Antarctic; Antarc*
• Online Access: http://hdl.handle.net/2440/51294; https://doi.org/10.1021/cr900032s

Variolin B, a novel marine alkaloid that was isolated from the rare and difficult-to-access, Antarctic sponge Kirkpatrickia varialosa by the group of Blunt and Munro, is a cyclin-dependent kinases (CDK). despite their modest size, the variolins presented a challenge in their structural elucidation b...