Variolins and related alkaloids

Variolin B, a novel marine alkaloid that was isolated from the rare and difficult-to-access, Antarctic sponge Kirkpatrickia varialosa by the group of Blunt and Munro, is a cyclin-dependent kinases (CDK). despite their modest size, the variolins presented a challenge in their structural elucidation b...

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Bibliographic Details
Published in:Chemical Reviews
Main Authors: Walker, S., Carter, E., Huff, B., Morris, J.
Format: Article in Journal/Newspaper
Language:English
Published: Amer Chemical Soc 2009
Subjects:
Aza Compounds
Indole Alkaloids
Pyrimidines
Cyclin-Dependent Kinases
Antineoplastic Agents
Bridged Bicyclo Compounds
Heterocyclic
Antarctic
Hernandez
Palermo
The Antarctic
Antarc*
Online Access:http://hdl.handle.net/2440/51294
https://doi.org/10.1021/cr900032s
Description
Summary:Variolin B, a novel marine alkaloid that was isolated from the rare and difficult-to-access, Antarctic sponge Kirkpatrickia varialosa by the group of Blunt and Munro, is a cyclin-dependent kinases (CDK). despite their modest size, the variolins presented a challenge in their structural elucidation because of the presence of several ring-nitrogen atoms and relatively few hydrogen atoms in the structure. Hernandez Franco and Palermo reported the isolation of five 3-(2-aminopyrimidine)indoles, which were named meridianins A-E from the tunicate Apidium meridianum which has been collected at a depth of 100 m near the South Georgia Islands. The aplicyanin family was isolated from the Antarctic tunicate Aplidium cyaneum and consists of six variants on a core 3-(tetrahydropyrimidyl) indole structure. Kuhn and co-workers used their modeling software SLIDE to identify variolin B as the top candidate for the inhibition of the AsnRS found in Brugia malayi. Scott R. Walker, Erin J. Carter, Belinda C. Huff, and Jonathan C. Morris

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