Elevated catalase expression in a fungal pathogen is a double-edged sword of iron

• Published in: PLOS Pathogens
• Main Authors: Pradhan, Arnab, Herrero De Dios, Carmen, Belmonte, Rodrigo, Budge, Susan, Lopez Garcia, Angela, Kolmogorova, Aljona, LEE, Keunsook K, Martin, Brennan D, Ribeiro, Antonio, Bebes, Attila, Yuecel, Raif, Gow, Neil A R, Munro, Carol A, MacCallum, Donna M, Quinn, Janet, Brown, Alistair J P
• Other Authors: University of Aberdeen.Centre for Genome-Enabled Biology and Medicine, University of Aberdeen.Medicine, Medical Sciences & Nutrition, University of Aberdeen.Medical Sciences, University of Aberdeen.Applied Medicine, University of Aberdeen.MRC Centre for Medical Mycology
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2017
• Subjects: candida albicans; catalase; stress resistance; Iron homeostasis; fitness; host colonisation; virulence; QR Microbiology; Biotechnology and Biological Sciences Research Council (BBSRC); BB/F00513X/1; BB/K017365/1; BB/K016393/1; European Research Council; Medical Research Council (MRC); MR/M026663/1; Wellcome Trust; 080088; 097377; 088858/Z/09/Z; QR; Antarc*; Antarctic; British Antarctic Survey
• Online Access: http://hdl.handle.net/2164/8675; https://doi.org/10.1371/journal.ppat.1006405

We thank our colleagues in the Aberdeen Fungal Group, Lloyd Peck (British Antarctic Survey) and John Helmann (Cornell University) for insightful discussions. We thank Christophe d’Enfert and Melanie Legrand (Institut Pasteur) for help with the design of barcodes and provision of the CIp10-PTET-GTw overexpression vector and CEC2908 strain. We are grateful to the following Core Facilities at the University of Aberdeen for their excellent technical assistance, advice and support: the Medical Research Facility; the Centre for Genome Enabled Biology and Medicine; the Iain Fraser Cytometry Centre; the Microscopy and Histology Facility; Aberdeen Proteomics; and the qPCR Facility. Peer reviewed