| Summary: | The assessed research the adjuvant and immunomodulatory effect of natural apitoxin produced by Apis Mellifera on bacterial growth and blood parameters in domestic canines that presented pediatric lesions; For this, the experimental and descriptive method was applied, handling 15 dogs of different races and gender that were randomly placed in the treatments. The treatment with apitoxin consisted to controll bee stinging every 24 and 48 hours together with the use of cephalexin and medicated baths that allowed to verify the numerical variation of CFU (colony forming units) by culture at day 0 and 21, of each one of the patients, using the skin scraping and swab technique; being that the presence of Staphylococcus spp in 66.6% of the studied cases was determined in addition to evidencing variability of parameters performing a blood counting; before, at 15 and 21 days of treatment. As a therapeutic comparison was also made between the conventional treatment which consisted only of medicated chlorhexidine-based baths, and that which possesses apitoxin. Evaluating the suggestive clinical remission signs to canine pyoderma through a systematic clinical evaluation of the patient until day 21. Where it was obtained to application of apitoxin every 24 hours presents a greater physiological response of the body's immune system stabilizing its parameters at the end of the work. En el estudio se evaluó el efecto coadyuvante e inmunomodulador de la apitoxina natural producida por la Apis mellifera sobre el crecimiento bacteriano y parámetros sanguíneos en caninos domésticos que presentaron lesiones piodérmicas; para ello se aplicó el método experimental y descriptivo, manejando 15 canes de diferentes razas y sexo que fueron ubicados aleatoriamente en los tratamientos. El tratamiento con apitoxina consistió en la picadura controlada de abejas cada 24 y 48 horas conjuntamente con el uso de cefalexina y baños medicados que permitió verificar la variación numérica de las UFC mediante cultivo al día 0 y 21, de cada uno de los ...
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