Chemoenzymatic preparation of musky macrolactones

A chemoenzymatic approach to some musk macrolactones has been explored by the optimization of macrolactonization catalyzed by Candida antarctica lipase B (Novozym 435). This fast and high yield optimized methodology represents a large improvement to previously reported results. The methodology was a...

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Bibliographic Details
Published in:Tetrahedron
Main Authors: Fortunati, T., D'ACUNTO, MARIANTONIETTA, CARUSO, Tonino, SPINELLA, Aldo
Other Authors: D'Acunto, Mariantonietta, Caruso, Tonino, Spinella, Aldo
Format: Article in Journal/Newspaper
Language:English
Published: 2015
Subjects:
Antarc*
Antarctica
Online Access:http://hdl.handle.net/11386/4643698
https://doi.org/10.1016/j.tet.2015.03.007
http://www.sciencedirect.com/science/article/pii/S0040402015003051
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Summary:A chemoenzymatic approach to some musk macrolactones has been explored by the optimization of macrolactonization catalyzed by Candida antarctica lipase B (Novozym 435). This fast and high yield optimized methodology represents a large improvement to previously reported results. The methodology was applied to the preparation of 16-hexadecanolide, exaltolide, ambrettolide and (15R)-15-hexadecanolide

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