Isolation and Structure Characterization of Two Novel Bioactive Sulphated Polyhydroxysteroids from the Antarctic OphiuroidOphioderma longicaudum

• Published in: Natural Product Letters
• Main Authors: Maria Valeria D'auria, Luigi Gomez Paloma, Luigi Minale, Angela Zampella, Mariella Morbidoni, RICCIO, Raffaele
• Other Authors: Maria Valeria, D'Auria, Luigi Gomez, Paloma, Luigi, Minale, Riccio, Raffaele, Angela, Zampella, Mariella, Morbidoni
• Format: Article in Journal/Newspaper
• Language: English
• Published: 1993
• Subjects: Antarctic; The Antarctic; Antarc*
• Online Access: http://hdl.handle.net/11386/3128281; https://doi.org/10.1080/10575639308043863

Two novel sulfated polyhydroxysteroids, I, possessing potent cytotoxic activity, and II, which proved to be cytoprotective against HIV-1, were isolated from the Antarctic ophiuroid Ophiosparte gigas, together with the known compd. III. The structures of I and II were detd. to be cholest-5-ene-2α,3α,4β, 21-tetraol 3,21-disulfate and cholest-5-ene-2β,3α, 21-triol 2,21-disulfate, resp.