Isolation and Structure Characterization of Two Novel Bioactive Sulphated Polyhydroxysteroids from the Antarctic OphiuroidOphioderma longicaudum

Two novel sulfated polyhydroxysteroids, I, possessing potent cytotoxic activity, and II, which proved to be cytoprotective against HIV-1, were isolated from the Antarctic ophiuroid Ophiosparte gigas, together with the known compd. III. The structures of I and II were detd. to be cholest-5-ene-2α,3α,...

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Bibliographic Details
Published in:Natural Product Letters
Main Authors: Maria Valeria D'auria, Luigi Gomez Paloma, Luigi Minale, Angela Zampella, Mariella Morbidoni, RICCIO, Raffaele
Other Authors: Maria Valeria, D'Auria, Luigi Gomez, Paloma, Luigi, Minale, Riccio, Raffaele, Angela, Zampella, Mariella, Morbidoni
Format: Article in Journal/Newspaper
Language:English
Published: 1993
Subjects:
Antarctic
The Antarctic
Antarc*
Online Access:http://hdl.handle.net/11386/3128281
https://doi.org/10.1080/10575639308043863
Description
Summary:Two novel sulfated polyhydroxysteroids, I, possessing potent cytotoxic activity, and II, which proved to be cytoprotective against HIV-1, were isolated from the Antarctic ophiuroid Ophiosparte gigas, together with the known compd. III. The structures of I and II were detd. to be cholest-5-ene-2α,3α,4β, 21-tetraol 3,21-disulfate and cholest-5-ene-2β,3α, 21-triol 2,21-disulfate, resp.

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