A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans

• Published in: American Journal of Physical Anthropology
• Main Authors: Reales, Guillermo, Rovaris, Diego L., Jacovas, Vanessa C., Hünemeier, Tábita, Sandoval, José R., Salazar Granara, Alcibiades, Demarchi, Dario, Tarazona Santos, Eduardo, Felkl, Aline B., Serafini, Michele A., Salzano, Francisco M., Bisso Machado, Rafael, Comas, David, Paixão Côrtes, Vanessa R., Bortolini, Maria Catira
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley-liss, Div John Wiley & Sons Inc 2021
• Subjects: ADAPTATION; APOE; MODE OF SUBSISTENCE; PLEIOTROPY; Otras Ciencias Biológicas; Ciencias Biológicas; CIENCIAS NATURALES Y EXACTAS; Genética y Herencia; Argentina; San Martín; Uruguay; Saqqaq
• Online Access: http://suquia.ffyh.unc.edu.ar/handle/11336/63293; http://hdl.handle.net/11336/63293

Objectives: To determine genetic differences between agriculturalist and hunter-gatherer southern Native American populations for selected metabolism-related markers and to test whether Neel's thrifty genotype hypothesis (TGH) could explain the genetic patterns observed in these populations. Materials and Methods: 375 Native South American individuals from 17 populations were genotyped using six markers (APOE rs429358 and rs7412; APOA2 rs5082; CD36 rs3211883; TCF7L2 rs11196205; and IGF2BP2 rs11705701). Additionally, APOE genotypes from 39 individuals were obtained from the literature. AMOVA, main effects, and gene-gene interaction tests were performed. Results: We observed differences in allele distribution patterns between agriculturalists and hunter-gatherers for some markers. For instance, between-groups component of genetic variance (FCT) for APOE rs429358 showed strong differences in allelic distributions between hunter-gatherers and agriculturalists (p = 0.00196). Gene-gene interaction analysis indicated that the APOE E4/CD36 TT and APOE E4/IGF2BP2 A carrier combinations occur at a higher frequency in hunter-gatherers, but this combination is not replicated in archaic (Neanderthal and Denisovan) and ancient (Anzick, Saqqaq, Ust-Ishim, Mal'ta) hunter-gatherer individuals. Discussion: A complex scenario explains the observed frequencies of the tested markers in hunter-gatherers. Different factors, such as pleotropic alleles, rainforest selective pressures, and population dynamics, may be collectively shaping the observed genetic patterns. We conclude that although TGH seems a plausible hypothesis to explain part of the data, other factors may be important in our tested populations. Fil: Reales, Guillermo. Universidade Federal do Rio Grande do Sul; Brasil Fil: Rovaris, Diego L. Universidade Federal do Rio Grande do Sul; Brasil Fil: Jacovas, Vanessa C. Universidade Federal do Rio Grande do Sul; Brasil Fil: Hünemeier, Tábita. Universidade de Sao Paulo; Brasil Fil: Sandoval, José R. Universidad de San Martín de Porres. Facultad de Medicina Humana; Perú Fil: Salazar Granara, Alcibiades. Universidad de San Martín de Porres. Facultad de Medicina Humana; Perú Fil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; Argentina Fil: Tarazona Santos, Eduardo. Universidade Federal de Minas Gerais; Brasil Fil: Felkl, Aline B. Universidade Federal do Rio Grande do Sul; Brasil Fil: Serafini, Michele A. Universidade Federal do Rio Grande do Sul; Brasil Fil: Salzano, Francisco M. Universidade Federal do Rio Grande do Sul; Brasil Fil: Bisso Machado, Rafael. Universidad de la República; Uruguay Fil: Comas, David. Universitat Pompeu Fabra; España Fil: Paixão Côrtes, Vanessa R. Universidade Federal da Bahia; Brasil Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil