Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas

• Published in: Developmental & Comparative Immunology
• Main Authors: Montagnani, C., Labreuche, Y., Escoubas, Jean-Michel
• Other Authors: Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Medical University of South Carolina Charleston (MUSC), Ecologie microbienne des insectes et interactions hôte-pathogène (EMIP), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2008
• Subjects: SIGNALING PATHWAY; Nf-κB; IκB; INNATE IMMUNITY; ANKYRIN; CRASSOSTREA GIGAS; OYSTER; MOLLUSC; INVERTEBRATE; HUITRE CREUSE; [SDV.IMM]Life Sciences [q-bio]/Immunology; Pacific; Crassostrea gigas; Pacific oyster
• Online Access: https://hal.inrae.fr/hal-02660632; https://doi.org/10.1016/j.dci.2007.06.001

International audience Inhibitors of NF-κB (IκBs) have been implicated as major components of the Rel/NF-κB signaling pathway, which is an important mediator of immune responses throughout much of the animal kingdom. Here we report the first characterization of a bivalve mollusc cDNA that encodes a novel IκB member called Cg-IκB showing the conservation of most IκB protein characteristics. Sequences as well as phylogenetic analyses reveal a high level of identity between not only Cg-IκB and other mollusc and insect IκB-like proteins but also similarities to vertebrate IκB-α and -ε isoforms. Expression analyses demonstrated that the transcript is widely expressed in all oyster tissues. This work is consistent with our previous discovery of several members of an NF-κB pathway in Crassostrea gigas and further sustains the hypothesis of a conserved scheme of immune gene regulation through most of the metazoans.