Concurrent decrease of vasopressin and protein kinase C-alpha immunoreactivity during the light phase in the vole suprachiasmatic nucleus
Vasopressin (AVP) is a major neuropeptide in the suprachiasmatic nucleus, the mammalian hypothalamic circadian pacemaker. Protein kinase C alpha is a putatively coupled intracellular messenger. Mean numbers of AVP- and protein kinase C alpha- immunoreactive neurons were determined in the suprachiasm...
| Main Authors: | , , |
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| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
1998
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| Subjects: | |
| Online Access: | http://hdl.handle.net/11370/b03bee47-90b4-43f9-92d5-094bf9ae24bf https://research.rug.nl/en/publications/concurrent-decrease-of-vasopressin-and-protein-kinase-calpha-immunoreactivity-during-the-light-phase-in-the-vole-suprachiasmatic-nucleus(b03bee47-90b4-43f9-92d5-094bf9ae24bf).html |
| Summary: | Vasopressin (AVP) is a major neuropeptide in the suprachiasmatic nucleus, the mammalian hypothalamic circadian pacemaker. Protein kinase C alpha is a putatively coupled intracellular messenger. Mean numbers of AVP- and protein kinase C alpha- immunoreactive neurons were determined in the suprachiasmatic nucleus of common voles, entrained to a 12:12 h light-dark (LD) cycle, at the beginning of the light period (zeitgeber time zero) and 6 h later (zeitgeber time six). At zeitgeber time zero, mean numbers of AVP- and protein kinase C alpha- immunoreactive neurons were 2194 and 9897, respectively. Both numbers decreased significantly with about 40% at zeitgeber time six. This concurrent decrease was most pronounced in the dorsomedial aspect of the suprachiasmatic nucleus. These findings are consistent with the findings of a peak of AVP release in rats during the early light phase. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved |
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