Standard of hygiene and immune adaptation in newborn infants
The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood...
Published in: | Clinical Immunology |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2014
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Online Access: | https://hdl.handle.net/11370/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 https://research.rug.nl/en/publications/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 https://doi.org/10.1016/j.clim.2014.09.009 https://pure.rug.nl/ws/files/117134630/Standard_of_hygiene_and_immune_adaptation_in_newborn_infants.pdf |
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ftunigroningenpu:oai:pure.rug.nl:publications/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 2024-06-23T07:54:19+00:00 Standard of hygiene and immune adaptation in newborn infants Kallionpaa, Henna Laajala, Essi Oling, Viveka Harkonen, Taina Tillmann, Vallo Dorshakova, Natalya V. Ilonen, Jorma Landesmaki, Harri Knip, Mikael Lahesmaa, Riitta Koski, Katriina Koski, Matti Ryhanen, Samppa Siljander, Heli Hamalainen, Anu-Maaria Ormisson, Anne Peet, Aleksandr Ulich, Valentina Kuzmicheva, Elena Mokurov, Sergei Markova, Svettana Pylova, Svetlana Isakova, Marina Shakurova, Elena Petrov, Vladimir Karapetyan, Tatyana Varlamova, Tatyana Kiviniemi, Minna Alnek, Kristi Janson, Helis Uibo, Raivo Salum, Tiit von Mutius, Erika Weber, Juliane Ahlfors, Helena Moulder, Robert Nieminen, Janne Ruohtula, Terhi Vaarala, Outi Honkanen, Hanna Hyoty, Heikki Kondrashova, Anita Oikarinen, Sami Harmsen, Hermie J. M. De Goffau, Marcus C. Welling, Gjalt Alahuhta, Kirsi Korhonen, Tuuli Virtanen, Suvi M. 2014-11 application/pdf https://hdl.handle.net/11370/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 https://research.rug.nl/en/publications/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 https://doi.org/10.1016/j.clim.2014.09.009 https://pure.rug.nl/ws/files/117134630/Standard_of_hygiene_and_immune_adaptation_in_newborn_infants.pdf eng eng https://research.rug.nl/en/publications/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 info:eu-repo/semantics/openAccess Kallionpaa , H , Laajala , E , Oling , V , Harkonen , T , Tillmann , V , Dorshakova , N V , Ilonen , J , Landesmaki , H , Knip , M , Lahesmaa , R , Koski , K , Koski , M , Ryhanen , S , Siljander , H , Hamalainen , A-M , Ormisson , A , Peet , A , Ulich , V , Kuzmicheva , E , Mokurov , S , Markova , S , Pylova , S , Isakova , M , Shakurova , E , Petrov , V , Karapetyan , T , Varlamova , T , Ilonen , J , Kiviniemi , M , Alnek , K , Janson , H , Uibo , R , Salum , T , von Mutius , E , Weber , J , Ahlfors , H , Moulder , R , Nieminen , J , Ruohtula , T , Vaarala , O , Honkanen , H , Hyoty , H , Kondrashova , A , Oikarinen , S , Harmsen , H J M , De Goffau , M C , Welling , G , Alahuhta , K , Korhonen , T , Virtanen , S M & DIABIMMUNE Study Grp 2014 , ' Standard of hygiene and immune adaptation in newborn infants ' , Clinical Immunology , vol. 155 , no. 1 , pp. 136-147 . https://doi.org/10.1016/j.clim.2014.09.009 Hygiene hypothesis Newborn infant Cord blood Gene expression Innate immunity Immune adaptation REGULATORY T-CELLS RUSSIAN KARELIA MULTIPLE-SCLEROSIS DENDRITIC CELLS EXPRESSION RECEPTOR RESPONSES FINLAND CD46 article 2014 ftunigroningenpu https://doi.org/10.1016/j.clim.2014.09.009 2024-06-10T16:15:12Z The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu. (C) 2014 The Authors. Published by Elsevier Inc. Article in Journal/Newspaper karelia* karelia* karelian Republic of Karelia University of Groningen research database Clinical Immunology 155 1 136 147 |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
topic |
Hygiene hypothesis Newborn infant Cord blood Gene expression Innate immunity Immune adaptation REGULATORY T-CELLS RUSSIAN KARELIA MULTIPLE-SCLEROSIS DENDRITIC CELLS EXPRESSION RECEPTOR RESPONSES FINLAND CD46 |
spellingShingle |
Hygiene hypothesis Newborn infant Cord blood Gene expression Innate immunity Immune adaptation REGULATORY T-CELLS RUSSIAN KARELIA MULTIPLE-SCLEROSIS DENDRITIC CELLS EXPRESSION RECEPTOR RESPONSES FINLAND CD46 Kallionpaa, Henna Laajala, Essi Oling, Viveka Harkonen, Taina Tillmann, Vallo Dorshakova, Natalya V. Ilonen, Jorma Landesmaki, Harri Knip, Mikael Lahesmaa, Riitta Koski, Katriina Koski, Matti Ryhanen, Samppa Siljander, Heli Hamalainen, Anu-Maaria Ormisson, Anne Peet, Aleksandr Ulich, Valentina Kuzmicheva, Elena Mokurov, Sergei Markova, Svettana Pylova, Svetlana Isakova, Marina Shakurova, Elena Petrov, Vladimir Karapetyan, Tatyana Varlamova, Tatyana Kiviniemi, Minna Alnek, Kristi Janson, Helis Uibo, Raivo Salum, Tiit von Mutius, Erika Weber, Juliane Ahlfors, Helena Moulder, Robert Nieminen, Janne Ruohtula, Terhi Vaarala, Outi Honkanen, Hanna Hyoty, Heikki Kondrashova, Anita Oikarinen, Sami Harmsen, Hermie J. M. De Goffau, Marcus C. Welling, Gjalt Alahuhta, Kirsi Korhonen, Tuuli Virtanen, Suvi M. Standard of hygiene and immune adaptation in newborn infants |
topic_facet |
Hygiene hypothesis Newborn infant Cord blood Gene expression Innate immunity Immune adaptation REGULATORY T-CELLS RUSSIAN KARELIA MULTIPLE-SCLEROSIS DENDRITIC CELLS EXPRESSION RECEPTOR RESPONSES FINLAND CD46 |
description |
The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu. (C) 2014 The Authors. Published by Elsevier Inc. |
format |
Article in Journal/Newspaper |
author |
Kallionpaa, Henna Laajala, Essi Oling, Viveka Harkonen, Taina Tillmann, Vallo Dorshakova, Natalya V. Ilonen, Jorma Landesmaki, Harri Knip, Mikael Lahesmaa, Riitta Koski, Katriina Koski, Matti Ryhanen, Samppa Siljander, Heli Hamalainen, Anu-Maaria Ormisson, Anne Peet, Aleksandr Ulich, Valentina Kuzmicheva, Elena Mokurov, Sergei Markova, Svettana Pylova, Svetlana Isakova, Marina Shakurova, Elena Petrov, Vladimir Karapetyan, Tatyana Varlamova, Tatyana Kiviniemi, Minna Alnek, Kristi Janson, Helis Uibo, Raivo Salum, Tiit von Mutius, Erika Weber, Juliane Ahlfors, Helena Moulder, Robert Nieminen, Janne Ruohtula, Terhi Vaarala, Outi Honkanen, Hanna Hyoty, Heikki Kondrashova, Anita Oikarinen, Sami Harmsen, Hermie J. M. De Goffau, Marcus C. Welling, Gjalt Alahuhta, Kirsi Korhonen, Tuuli Virtanen, Suvi M. |
author_facet |
Kallionpaa, Henna Laajala, Essi Oling, Viveka Harkonen, Taina Tillmann, Vallo Dorshakova, Natalya V. Ilonen, Jorma Landesmaki, Harri Knip, Mikael Lahesmaa, Riitta Koski, Katriina Koski, Matti Ryhanen, Samppa Siljander, Heli Hamalainen, Anu-Maaria Ormisson, Anne Peet, Aleksandr Ulich, Valentina Kuzmicheva, Elena Mokurov, Sergei Markova, Svettana Pylova, Svetlana Isakova, Marina Shakurova, Elena Petrov, Vladimir Karapetyan, Tatyana Varlamova, Tatyana Kiviniemi, Minna Alnek, Kristi Janson, Helis Uibo, Raivo Salum, Tiit von Mutius, Erika Weber, Juliane Ahlfors, Helena Moulder, Robert Nieminen, Janne Ruohtula, Terhi Vaarala, Outi Honkanen, Hanna Hyoty, Heikki Kondrashova, Anita Oikarinen, Sami Harmsen, Hermie J. M. De Goffau, Marcus C. Welling, Gjalt Alahuhta, Kirsi Korhonen, Tuuli Virtanen, Suvi M. |
author_sort |
Kallionpaa, Henna |
title |
Standard of hygiene and immune adaptation in newborn infants |
title_short |
Standard of hygiene and immune adaptation in newborn infants |
title_full |
Standard of hygiene and immune adaptation in newborn infants |
title_fullStr |
Standard of hygiene and immune adaptation in newborn infants |
title_full_unstemmed |
Standard of hygiene and immune adaptation in newborn infants |
title_sort |
standard of hygiene and immune adaptation in newborn infants |
publishDate |
2014 |
url |
https://hdl.handle.net/11370/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 https://research.rug.nl/en/publications/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 https://doi.org/10.1016/j.clim.2014.09.009 https://pure.rug.nl/ws/files/117134630/Standard_of_hygiene_and_immune_adaptation_in_newborn_infants.pdf |
genre |
karelia* karelia* karelian Republic of Karelia |
genre_facet |
karelia* karelia* karelian Republic of Karelia |
op_source |
Kallionpaa , H , Laajala , E , Oling , V , Harkonen , T , Tillmann , V , Dorshakova , N V , Ilonen , J , Landesmaki , H , Knip , M , Lahesmaa , R , Koski , K , Koski , M , Ryhanen , S , Siljander , H , Hamalainen , A-M , Ormisson , A , Peet , A , Ulich , V , Kuzmicheva , E , Mokurov , S , Markova , S , Pylova , S , Isakova , M , Shakurova , E , Petrov , V , Karapetyan , T , Varlamova , T , Ilonen , J , Kiviniemi , M , Alnek , K , Janson , H , Uibo , R , Salum , T , von Mutius , E , Weber , J , Ahlfors , H , Moulder , R , Nieminen , J , Ruohtula , T , Vaarala , O , Honkanen , H , Hyoty , H , Kondrashova , A , Oikarinen , S , Harmsen , H J M , De Goffau , M C , Welling , G , Alahuhta , K , Korhonen , T , Virtanen , S M & DIABIMMUNE Study Grp 2014 , ' Standard of hygiene and immune adaptation in newborn infants ' , Clinical Immunology , vol. 155 , no. 1 , pp. 136-147 . https://doi.org/10.1016/j.clim.2014.09.009 |
op_relation |
https://research.rug.nl/en/publications/93285ea5-cae9-42ab-a4ee-e5b2bd66e476 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.clim.2014.09.009 |
container_title |
Clinical Immunology |
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155 |
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136 |
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147 |
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