Prevalence of asymptomatic carotid artery stenosis in the general population:an individual participant data meta-analysis

Background and Purpose-In the discussion on the cost-effectiveness of screening, precise estimates of severe asymptomatic carotid stenosis are vital. Accordingly, we assessed the prevalence of moderate and severe asymptomatic carotid stenosis by age and sex using pooled cohort data. Methods-We perfo...

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Bibliographic Details
Published in:Stroke
Main Authors: de Weerd, Marjolein, Greving, Jacoba P., Hedblad, Bo, Lorenz, Matthias W., Mathiesen, Ellisiv B., O'Leary, Daniel H., Rosvall, Maria, Sitzer, Matthias, Buskens, Erik, Bots, Michiel L.
Format: Article in Journal/Newspaper
Language:English
Published: 2010
Subjects:
carotid stenosis
epidemiology
stroke
RISK-FACTORS
ENDARTERECTOMY
PREVENTION
DISEASE
ATHEROSCLEROSIS
MALMO
AGE
Tromso
Online Access:https://hdl.handle.net/11370/484a102e-9d9b-49cc-b29b-41bfbc76125c
https://research.rug.nl/en/publications/484a102e-9d9b-49cc-b29b-41bfbc76125c
https://doi.org/10.1161/STROKEAHA.110.581058
Description
Summary:Background and Purpose-In the discussion on the cost-effectiveness of screening, precise estimates of severe asymptomatic carotid stenosis are vital. Accordingly, we assessed the prevalence of moderate and severe asymptomatic carotid stenosis by age and sex using pooled cohort data. Methods-We performed an individual participant data meta-analysis (23 706 participants) of 4 population-based studies (Malmo Diet and Cancer Study, Tromso, Carotid Atherosclerosis Progression Study, and Cardiovascular Health Study). Outcomes of interest were asymptomatic moderate (>= 50%) and severe carotid stenosis (>= 70%). Results-Prevalence of moderate asymptomatic carotid stenosis ranged from 0.2% (95% CI, 0.0% to 0.4%) in men aged = 80 years. For women, this prevalence increased from 0% (0% to 0.2%) to 5.0% (3.1% to 7.5%). Prevalence of severe asymptomatic carotid stenosis ranged from 0.1% (0.0% to 0.3%) in men aged = 80. For women, this prevalence increased from 0% (0.0% to 0.2%) to 0.9% (0.3% to 2.4%). Conclusions-The prevalence of severe asymptomatic carotid stenosis in the general population ranges from 0% to 3.1%, which is useful information in the discussion on the cost-effectiveness of screening. (Stroke. 2010; 41: 1294-1297.)

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