Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two...

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Bibliographic Details
Main Authors: Maier, M.S., Roccatagliata, A.J., Kuriss, A., Chludil, H., Seldes, A.M., Pujol, C.A., Damonte, E.B.
Format: Journal/Newspaper
Language:unknown
Subjects:
antivirus agent
liouvilloside A
liouvilloside B
triterpene derivative
unclassified drug
antiviral activity
article
cytostasis
cytotoxicity
drug isolation
echinoderm
Herpes simplex virus 1
immunomodulation
structure analysis
sulfation
Animals
Antineoplastic Agents
Antiviral Agents
Carbohydrate Conformation
Cercopithecus aethiops
Drug Screening Assays
Antitumor
Herpesvirus 1
Human
Hydrolysis
Magnetic Resonance Spectroscopy
Methylation
Microbial Sensitivity Tests
Oligosaccharides
Sea Cucumbers
Spectrometry
Mass
Fast Atom Bombardment
Triterpenes
Vero Cells
Antarc*
Antarctic
Online Access:https://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier
id ftunibueairesbd:todo:paper_01633864_v64_n6_p732_Maier
record_format openpolar
spelling ftunibueairesbd:todo:paper_01633864_v64_n6_p732_Maier 2023-10-29T02:32:04+01:00 Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei Maier, M.S. Roccatagliata, A.J. Kuriss, A. Chludil, H. Seldes, A.M. Pujol, C.A. Damonte, E.B. https://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier unknown http://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar antivirus agent liouvilloside A liouvilloside B triterpene derivative unclassified drug antiviral activity article cytostasis cytotoxicity drug isolation echinoderm Herpes simplex virus 1 immunomodulation structure analysis sulfation Animals Antineoplastic Agents Antiviral Agents Carbohydrate Conformation Cercopithecus aethiops Drug Screening Assays Antitumor Herpesvirus 1 Human Hydrolysis Magnetic Resonance Spectroscopy Methylation Microbial Sensitivity Tests Oligosaccharides Sea Cucumbers Spectrometry Mass Fast Atom Bombardment Triterpenes Vero Cells JOUR ftunibueairesbd https://doi.org/20.500.12110/paper_01633864_v64_n6_p732_Maier 2023-10-05T01:57:58Z Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL. Journal/Newspaper Antarc* Antarctic Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires)
institution Open Polar
collection Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires)
op_collection_id ftunibueairesbd
language unknown
topic antivirus agent
liouvilloside A
liouvilloside B
triterpene derivative
unclassified drug
antiviral activity
article
cytostasis
cytotoxicity
drug isolation
echinoderm
Herpes simplex virus 1
immunomodulation
structure analysis
sulfation
Animals
Antineoplastic Agents
Antiviral Agents
Carbohydrate Conformation
Cercopithecus aethiops
Drug Screening Assays
Antitumor
Herpesvirus 1
Human
Hydrolysis
Magnetic Resonance Spectroscopy
Methylation
Microbial Sensitivity Tests
Oligosaccharides
Sea Cucumbers
Spectrometry
Mass
Fast Atom Bombardment
Triterpenes
Vero Cells
spellingShingle antivirus agent
liouvilloside A
liouvilloside B
triterpene derivative
unclassified drug
antiviral activity
article
cytostasis
cytotoxicity
drug isolation
echinoderm
Herpes simplex virus 1
immunomodulation
structure analysis
sulfation
Animals
Antineoplastic Agents
Antiviral Agents
Carbohydrate Conformation
Cercopithecus aethiops
Drug Screening Assays
Antitumor
Herpesvirus 1
Human
Hydrolysis
Magnetic Resonance Spectroscopy
Methylation
Microbial Sensitivity Tests
Oligosaccharides
Sea Cucumbers
Spectrometry
Mass
Fast Atom Bombardment
Triterpenes
Vero Cells
Maier, M.S.
Roccatagliata, A.J.
Kuriss, A.
Chludil, H.
Seldes, A.M.
Pujol, C.A.
Damonte, E.B.
Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
topic_facet antivirus agent
liouvilloside A
liouvilloside B
triterpene derivative
unclassified drug
antiviral activity
article
cytostasis
cytotoxicity
drug isolation
echinoderm
Herpes simplex virus 1
immunomodulation
structure analysis
sulfation
Animals
Antineoplastic Agents
Antiviral Agents
Carbohydrate Conformation
Cercopithecus aethiops
Drug Screening Assays
Antitumor
Herpesvirus 1
Human
Hydrolysis
Magnetic Resonance Spectroscopy
Methylation
Microbial Sensitivity Tests
Oligosaccharides
Sea Cucumbers
Spectrometry
Mass
Fast Atom Bombardment
Triterpenes
Vero Cells
description Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL.
format Journal/Newspaper
author Maier, M.S.
Roccatagliata, A.J.
Kuriss, A.
Chludil, H.
Seldes, A.M.
Pujol, C.A.
Damonte, E.B.
author_facet Maier, M.S.
Roccatagliata, A.J.
Kuriss, A.
Chludil, H.
Seldes, A.M.
Pujol, C.A.
Damonte, E.B.
author_sort Maier, M.S.
title Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_short Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_full Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_fullStr Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_full_unstemmed Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_sort two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber staurocucumis liouvillei
url https://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier
genre Antarc*
Antarctic
genre_facet Antarc*
Antarctic
op_relation http://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier
op_rights info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
op_doi https://doi.org/20.500.12110/paper_01633864_v64_n6_p732_Maier
_version_ 1781053107813220352

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